HDAC3

Gene Symbol	HDAC3
Entrez Gene	8841
Alt Symbol	HD3, RPD3, RPD3-2
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 3
Other Description	SMAP45
Swissprots	O15379 D3DQE1 O43268 Q9UEV0 Q9UEI5
Accessions	AAC08351 AAC08352 AAC26509 BAG70923 EAW61915 EAW61916 EAW61917 EAW61918 O15379 AF005482 AAB87752 AF039703 AAC98927 AY429537 AY429538 BC000614 AAH00614 BM461585 DB456387 DQ891916 ABM82842 DQ895101 ABM86027 U66914 AAC52038 U75696 AAB88240 U75697 AAB88241 XM_011537697 XP_011535999 XR_944336 NM_003883 NP_003874
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with X
Subcellular Location	Nucleus. Cytoplasm {ECO:0000269|PubMed:25190803}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). {ECO:0000269|PubMed:25190803}.
Tissue Specificity	Widely expressed.
Top Pathways	Viral carcinogenesis, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HDAC3-Over-expression-Lysate - LY14135a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

HDAC3 293T Cell Transient Overexpression Lysate(Denatured) - H00008841-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

HDAC3 overexpression lysate - LY401280 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HDAC3 293 Cell Lysate - 401176 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

HDAC3 Overexpression Lysate (Denatured) - H00008841-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

HDAC3 Overexpression Lysate (Native) - NBL1-11481 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HDAC3 Over-expression Lysate Product - GWB-A73162 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human HDAC3 / Histone deacetylase 3 Insect Cell Lysate (WB positive control) - 11511-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

HDAC3 Overexpression Lysate (Denatured) - H00008841-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human HDAC3 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175054 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human HDAC3 Knockdown Stable Cell Line - CSC-DC006888 from Creative biogene Category Cell Line Species Human

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