IFNAR2

Gene Symbol IFNAR2
Entrez Gene 3455
Alt Symbol IFN-R, IFN-alpha-REC, IFNABR, IFNARB
Species Human
Gene Type protein-coding
Description interferon (alpha, beta and omega) receptor 2
Other Description IFN-R-2|IFN-alpha/beta receptor 2|human interferon alpha/beta receptor|interferon alpha binding protein|interferon alpha/beta receptor 2|interferon-alpha/beta receptor beta chain|type I interferon receptor 2
Swissprots A8KAJ4 Q6FHD7 Q15467 P48551 D3DSE9 D3DSE8
Accessions AAB46417 AAB46418 AAB46419 AAU21038 EAX09842 EAX09843 EAX09844 EAX09845 EAX09846 P48551 AK293059 BAF85748 BC002793 AAH02793 BC013156 BG715143 BI520056 BM677386 CD110317 CR541817 CAG46616 DQ893015 ABM83941 DQ896260 ABM87259 HG380509 CDG37809 HY104613 L41942 AAB46413 L41943 AAB46414 L41944 AAB46415 U29584 AAC50202 X77722 CAA54785 X89772 CAA61914 X89814 CAA61940 NM_000874 NP_000865 NM_001289125 NP_001276054 NM_001289126 NP_001276055 NM_001289128 NP_001276057 NM_207584 NP_997467 NM_207585 NP_997468
Function Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. {ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.
Subcellular Location Isoform 3: Secreted.
Tissue Specificity Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. {ECO:0000269|PubMed:7588638, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.
Top Pathways Osteoclast differentiation, PI3K-Akt signaling pathway, Herpes simplex infection, Influenza A, Measles

IFN-α/βRβ (H-300) - sc-30014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IFN-α/βRβ (H-300): sc-30014. Western blot analysis of IFN-α/βRβ expression in non-transfected: sc-117752 (A) and human IFN-α/βRβ transfected: sc-159501 (B) 293T whole cell lysates.

IFN-α/βRβ (C-18) - sc-704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IFN-α/βRβ (C-18): sc-704. Western blot analysis of IFN-α/βRβ expression in K-562 whole cell lysate.

IFN-α/βRβ (N-16) - sc-83256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
IFN-a/bRb (N-16): sc-83256. Western blot analysis of IFN-a/bRb expression in HEK293 (A), Jurkat (B), K-562 (C), and Hep G2 (D) whole cell lysates.

IFN-α/βRβ (P-17) - sc-83257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
IF-αR2 (P-17): sc-83257. Western blot analysis of IF-αR2 expression in HEK293 (A), Jurkat (B), K-562 (C), Hep G2 (D) and Caco-2 (E) whole cell lysates.

IFN-α/βRβ (T-20) - sc-83258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
IF-αR2 (T-20): sc-83258. Western blot analysis of IF-αR2 expression in HEK293 (A), Jurkat (B) and K-562 (C) whole cell lysates.

Anti-IFNAR2 antibody - ab56070 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab56070 stained MCF7 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab56070, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-IFNAR2 antibody - ab51545 from Abcam

Prices $372.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-IFNAR2 antibody - ab193410 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IFNAR2 antibody (ab193410)Lane 1 : MCF7 cell lysateLane 2 : Raji cell lysateLane 3 : HepG2 cell lysateLane 4 : THP1 cell lysateLane 5 : SW480 cell lysateLane 6 : A549 cell lysateLane 7 : HeLa cell lysateLane 8 : mouse liver lysate

Anti-IFNAR2 antibody - ab104451 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab104451, at 5 µg/ml, staining IFNAR2 in formalin-fixed, paraffin-embedded Human Placenta by Immunohistochemistry, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IFNAR2 antibody - ab172003 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IFNAR2 antibody (ab172003) at 1 µg/mlLane 1 : IFNAR2 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-IFNAR2 antibody - ab172039 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IFNAR2 antibody (ab172039) at 1 µg/mlLane 1 : IFNAR2 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L), Peroxidase Conjugated at 1/7500 dilution

Anti-IFNAR2 antibody [KT5] - ab106644 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone KT5

Anti-IFNAR2 antibody - N-terminal - ab190664 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IFNAR2 antibody - N-terminal (ab190664) at 1/500 dilution + AD293 cell extract at 30 µg

Anti-IFNAR2 Antibody (APC) - LS-C143924 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-IFNAR2 Antibody (C-Terminus) - LS-C47096 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFNAR2 Antibody - LS-C285663 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFNAR2 Antibody (clone MMHAR-2, PE) - LS-C196130 from LifeSpan Bioscience

Prices $665.00
Sizes 50 tst
Host Mouse
Clonality Monoclonal
Clone MMHAR-2

Anti-IFNAR2 Antibody - LS-C308405 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IFNAR2 Antibody - LS-C311260 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFNAR2 Antibody - LS-C341112 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFNAR2 Antibody - LS-C335179 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using IFNAR2 antibody.

Anti-IFNAR2 Antibody (aa28-40) IHC-plus™ - LS-B3605 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-IFNAR2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3605 concentration 5 ug/ml.

Anti-IFNAR2 Antibody (CF) - LS-C143923 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

IFN-alpha/beta R2 Antibody - AF1083 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Recombinant Mouse Limitin (Catalog # 1535-LM) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the L‑929 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse Limitin (30 pg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IFN‑ alpha / beta R2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1083). The ND50 is typically 2-10 µg/mL.

IFN-alpha/beta R2 Antibody - AF4015 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of K562 human chronic myelogenous leukemia cell line. PVDF Membrane was probed with 1 µg/mL of Human IFN‑ alpha / beta R2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4015) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for IFN‑ alpha / beta R2 at approximately 58 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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