IFNAR2

Gene Symbol IFNAR2
Entrez Gene 3455
Alt Symbol IFN-R, IFN-alpha-REC, IFNABR, IFNARB
Species Human
Gene Type protein-coding
Description interferon (alpha, beta and omega) receptor 2
Other Description IFN-R-2|IFN-alpha/beta receptor 2|human interferon alpha/beta receptor|interferon alpha binding protein|interferon alpha/beta receptor 2|interferon-alpha/beta receptor beta chain|type I interferon receptor 2
Swissprots A8KAJ4 Q6FHD7 Q15467 P48551 D3DSE9 D3DSE8
Accessions AAB46417 AAB46418 AAB46419 AAU21038 EAX09842 EAX09843 EAX09844 EAX09845 EAX09846 P48551 AK293059 BAF85748 BC002793 AAH02793 BC013156 BG715143 BI520056 BM677386 CD110317 CR541817 CAG46616 DQ893015 ABM83941 DQ896260 ABM87259 HG380509 CDG37809 HY104613 L41942 AAB46413 L41943 AAB46414 L41944 AAB46415 U29584 AAC50202 X77722 CAA54785 X89772 CAA61914 X89814 CAA61940 NM_000874 NP_000865 NM_001289125 NP_001276054 NM_001289126 NP_001276055 NM_001289128 NP_001276057 NM_207584 NP_997467 NM_207585 NP_997468
Function Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. {ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.
Subcellular Location Isoform 3: Secreted.
Tissue Specificity Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. {ECO:0000269|PubMed:7588638, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.
Top Pathways Osteoclast differentiation, PI3K-Akt signaling pathway, Herpes simplex infection, Influenza A, Measles

IFN-α/βRβ siRNA (h) - sc-40091 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IFN-α/βRβ shRNA Plasmid (h) - sc-40091-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IFN-α/βRβ shRNA (h) Lentiviral Particles - sc-40091-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IFN-alpha/beta R2 RNAi - H00003455-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU070421 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1267 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1267 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IFNAR2 siRNA (Human) - CRH2342 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IFN-alpha/beta R2 RNAi - H00003455-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

IFN-alpha/beta R2 RNAi - H00003455-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

IFNAR2 - MBS8211127 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IFNAR2 (NM_000874.3) - SHH317129 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IFNAR2(NM_000874.3) - SHR174008 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IFNAR2(NM_207585.1) - SHR174570 from Creative biogene

Category siRNA
Species Reactivities Human

Human IFNAR2 siRNA - orb262844 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IFNAR2 shRNA Plasmid (Human) - CHH2342 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IFNAR2 miRNA 3'UTR clone - MiUTR1H-04814 from Creative biogene

Species Reactivities Human

IFNAR2 miRNA 3'UTR clone - MiUTR1H-04815 from Creative biogene

Species Reactivities Human

IFNAR2 miRNA 3'UTR clone - MiUTR3H-04924 from Creative biogene

Species Reactivities Human
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