SIX2

Gene Symbol SIX2
Entrez Gene 10736
Alt Symbol -
Species Human
Gene Type protein-coding
Description SIX homeobox 2
Other Description homeobox protein SIX2|sine oculis homeobox homolog 2
Swissprots Q9NPC8 Q9BXH7
Accessions AAF69031 AAK06773 AAK16583 EAX00265 Q9NPC8 AF136940 AAF69032 AF332196 AAK16581 AF332197 AAK16582 AI299144 AI697804 BC024033 AAH24033 BT020100 AAV38903 XM_005264100 XP_005264157 NM_016932 NP_058628
Function Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. Dur
Subcellular Location Nucleus {ECO:0000250|UniProtKB:Q62232}.
Tissue Specificity Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level). {ECO:0000269|PubMed:22703800}.

SIX2-Over-expression-Lysate - LY15762a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SIX2 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SIX2 gene‘

SIX2 293 Cell Lysate - 406641 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

SIX2 Overexpression Lysate (Native) - NBL1-15983 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SIX2 Overexpression Lysate (Adult Normal) [NBL1-15983] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SIX2.

SIX2 Over-expression Lysate Product - GWB-44D74E from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human SIX2 Knockdown Stable Cell Line - CSC-DC014277 from Creative biogene

Category Cell Line
Species Human
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