| Gene Symbol | SIX2 |
|---|---|
| Entrez Gene | 10736 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | SIX homeobox 2 |
| Other Description | homeobox protein SIX2|sine oculis homeobox homolog 2 |
| Swissprots | Q9NPC8 Q9BXH7 |
| Accessions | AAF69031 AAK06773 AAK16583 EAX00265 Q9NPC8 AF136940 AAF69032 AF332196 AAK16581 AF332197 AAK16582 AI299144 AI697804 BC024033 AAH24033 BT020100 AAV38903 XM_005264100 XP_005264157 NM_016932 NP_058628 |
| Function | Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. Dur |
| Subcellular Location | Nucleus {ECO:0000250|UniProtKB:Q62232}. |
| Tissue Specificity | Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level). {ECO:0000269|PubMed:22703800}. |
Human-SIX2-cDNA-Clone - DC05394 from Abgent, a WuXi AppTec company
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SIX2 - MBS1271213 from MyBioSource
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human SIX2 ORF clone - CDCH080480 from Creative Biomart
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human SIX2 ORF clone - CDCH080481 from Creative Biomart
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Human SIX2 ORF Clone(NM_016932.4) - CDCL175533 from Creative Biomart
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Human SIX2 ORF Clone (BC024033) - CDCS414374 from Creative biogene
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