SIX2

Gene Symbol SIX2
Entrez Gene 10736
Alt Symbol -
Species Human
Gene Type protein-coding
Description SIX homeobox 2
Other Description homeobox protein SIX2|sine oculis homeobox homolog 2
Swissprots Q9NPC8 Q9BXH7
Accessions AAF69031 AAK06773 AAK16583 EAX00265 Q9NPC8 AF136940 AAF69032 AF332196 AAK16581 AF332197 AAK16582 AI299144 AI697804 BC024033 AAH24033 BT020100 AAV38903 XM_005264100 XP_005264157 NM_016932 NP_058628
Function Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. Dur
Subcellular Location Nucleus {ECO:0000250|UniProtKB:Q62232}.
Tissue Specificity Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level). {ECO:0000269|PubMed:22703800}.

Six2 (C-13) - sc-67834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Six2 (H-40) - sc-135274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Six2 (S-16) - sc-67837 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Six2 (S-16): sc-67837. Western blot analysis of Six2 expression in mouse kidney tissue extract.

Six2 (NB-A37) - sc-135560 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Six2 (NB-A37): sc-135560. Western blot analysis of Six2 expression in human Six2 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-SIX2 antibody - ab68908 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab68908 staining SIX2 in Mouse Kidney by ICC/IF (Immunocytochemistry/immunofluorescence) 72 hours after Tamoxifen administration to pregnant mice. Cells were fixed with 4% paraformaldehyde and embedded in paraffin. Samples were incubated with primary antibody (1/200) An  Alexa Fluor®546-conjugated anti-rabbit IgG polyclonal was used as the secondary antibody. Counter stained with anti- Ac Tubulin and Nuclei stained with DAPI.The number of primary cilia (green) is markedly decreased in both SIX2-positive cells (nephrogenic precursors) and in ureteric cellsKif3aTM kidney (E, asterisk) compared to WT kidney (D). Scale bar= 25 μm

Anti-SIX2 antibody - ab86389 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIX2 antibody (ab86389) at 1 µg/ml + Fetal muscle lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SIX2 antibody - ab173000 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SIX2 antibody (ab173000) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-SIX2 antibody - ab56755 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56755 SIX2 antibody at 1ug/ml.

Anti-SIX2 antibody [EPR4824] - ab111827 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4824
All lanes : Anti-SIX2 antibody [EPR4824] (ab111827) at 1/1000 dilutionLane 1 : Human skeletal muscle lysateLane 2 : Mouse skeletal muscle lysateLane 3 : Rat skeletal muscle lysateLane 4 : L6 lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SIX2 Antibody (aa88-119) - LS-C325125 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIX2 Antibody (aa89-119) - LS-C158975 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SIX2 Antibody western blot of 293 cell line lysates (35 ug/lane). The SIX2 antibody detected the SIX2 protein (arrow).

Anti-SIX2 Antibody (Internal, clone EPR4824) - LS-C138269 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4824
Western blot analysis on (A) human skeletal muscle, (B) mouse skeletal muscle, (C) rat skeletal muscle, and (D) L6 lysates using anti-SIX2 antibody.

Anti-SIX2 Antibody (aa264-277) - LS-C10189 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SIX2 Antibody (clone 1G11) - LS-C139133 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G11

Anti-SIX2 Antibody (aa89-119, AP) - LS-C240807 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIX2 Antibody (aa89-119, APC) - LS-C240809 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIX2 Antibody (aa89-119, Biotin) - LS-C240810 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIX2 Antibody (aa89-119, FITC) - LS-C240811 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIX2 Antibody (aa89-119, PE) - LS-C240814 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIX2 Antibody (aa35-84) - LS-C101742 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SIX2 antibody LS-C101742 Western blot of Fetal Muscle lysate.

Anti-SIX2 Antibody (aa89-119, Azide-free, HRP) - LS-C248163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

SIX2 Antibody (3D7) - H00010736-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D7
Western Blot: SIX2 Antibody (3D7) [H00010736-M01] - Analysis of SIX2 expression in transfected 293T cell line by SIX2 monoclonal antibody (M01), clone 3D7.Lane 1: SIX2 transfected lysate(32.3 KDa).Lane 2: Non-transfected lysate.

SIX2 Antibody - NBP2-13312 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SIX2 Antibody [NBP2-13312] - Staining of human kidney shows strong cytoplasmic positivity with granular pattern positivity in renal tubules.

SIX2 Polyclonal Antibody - bs-12365R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SIX2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12365R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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