SIX2

Gene Symbol	SIX2
Entrez Gene	10736
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SIX homeobox 2
Other Description	homeobox protein SIX2|sine oculis homeobox homolog 2
Swissprots	Q9NPC8 Q9BXH7
Accessions	AAF69031 AAK06773 AAK16583 EAX00265 Q9NPC8 AF136940 AAF69032 AF332196 AAK16581 AF332197 AAK16582 AI299144 AI697804 BC024033 AAH24033 BT020100 AAV38903 XM_005264100 XP_005264157 NM_016932 NP_058628
Function	Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. Dur
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:Q62232}.
Tissue Specificity	Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level). {ECO:0000269|PubMed:22703800}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIX2 full length protein - ab132611 from Abcam Category Protein Source Wheat germ Species Human

Human SIX2 peptide - ab75094 from Abcam Category Peptide

SIX2 Antibody Blocking Peptide - LS-E4948 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIX2 Antibody Blocking Peptide - LS-E14172 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SIX2 Protein - H00010736-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SIX2-Antibody-Center-Blocking-Peptide - BP17338c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIX2 - H00010736-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SIX2 - H00010736-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SIX2 fusion protein - Ag2124 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Homeobox protein SIX2(SIX2) - CSB-YP885681HU CSB-EP885681HU CSB-BP885681HU CSB-MP885681HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SIX2 - TP301328 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SIX2 Protein - NBP2-13312PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SIX2 Peptide, Human - M34GP14277H from Creative Peptides Category Peptide Source Synthetic. Species Human

Homeobox protein SIX2 (SIX2), Recombinant Protein - MBS1396766 from MyBioSource Category Protein Prices $1,045.00, $1,045.00, $1,275.00, $1,275.00, $1,625.00, $1,625.00, $2,090.00, $2,090.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SIX2 Recombinant Protein Antigen - NBP2-54917PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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