SIX2

Gene Symbol	SIX2
Entrez Gene	10736
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SIX homeobox 2
Other Description	homeobox protein SIX2|sine oculis homeobox homolog 2
Swissprots	Q9NPC8 Q9BXH7
Accessions	AAF69031 AAK06773 AAK16583 EAX00265 Q9NPC8 AF136940 AAF69032 AF332196 AAK16581 AF332197 AAK16582 AI299144 AI697804 BC024033 AAH24033 BT020100 AAV38903 XM_005264100 XP_005264157 NM_016932 NP_058628
Function	Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. Dur
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:Q62232}.
Tissue Specificity	Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level). {ECO:0000269|PubMed:22703800}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Six2 CRISPR/Cas9 KO Plasmid (h) - sc-402975 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 HDR Plasmid (h) - sc-402975-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 Double Nickase Plasmid (h) - sc-402975-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 Double Nickase Plasmid (h2) - sc-402975-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 CRISPR Activation Plasmid (h) - sc-402975-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 CRISPR Activation Plasmid (h2) - sc-402975-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 Lentiviral Activation Particles (h) - sc-402975-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 Lentiviral Activation Particles (h2) - sc-402975-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 siRNA (h) - sc-38786 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Six2 shRNA Plasmid (h) - sc-38786-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Six2 shRNA (h) Lentiviral Particles - sc-38786-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIX2 RNAi - H00010736-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SIX2 RNAi - H00010736-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU031031 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19368 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19368 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SIX2 siRNA (Human) - CRH7315 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SIX2 - MBS8201953 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Six2 CRISPR/Cas9 KO Plasmid (h2) - sc-402975-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Six2 HDR Plasmid (h2) - sc-402975-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human SIX2 (NM_016932.4) - SHH407848 from Creative biogene Category siRNA Species Reactivities Human

Human SIX2 siRNA - orb267817 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SIX2 shRNA Plasmid (Human) - CHH7315 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SIX2 miRNA 3'UTR clone - MiUTR3H-07277 from Creative biogene Species Reactivities Human

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