Gene Symbol | IREB2 |
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Entrez Gene | 3658 |
Alt Symbol | ACO3, IRP2, IRP2AD |
Species | Human |
Gene Type | protein-coding |
Description | iron-responsive element binding protein 2 |
Other Description | IRE-BP 2|iron regulatory protein 2|iron-responsive element-binding protein 2 |
Swissprots | Q9UF17 Q8WVK6 H0YKU0 P48200 Q13095 Q1HE21 A8KAC7 E1CJT9 Q59FQ7 |
Accessions | ABF47091 EAW99169 EAW99170 EAW99171 P48200 AB209403 BAD92640 AB586699 BAJ19024 AK027033 AK027034 AK292992 BAF85681 AL117613 AL133439 CAB62825 BC017880 AAH17880 BC117481 AAI17482 BC117483 AAI17484 BC143948 BX340905 CN290278 HQ258663 ADR83414 M58511 AAA69901 U20180 AAA79926 NM_004136 NP_004127 |
Function | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}. |
Subcellular Location | Cytoplasm. |
IRP-2 (4G11) - sc-33680 from Santa Cruz Biotechnology
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IRP-2 (14F7) - sc-33681 from Santa Cruz Biotechnology
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IRP-2 (H-63) - sc-367049 from Santa Cruz Biotechnology
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IRP-2 (V-21) - sc-14221 from Santa Cruz Biotechnology
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IRP-2 (7H6) - sc-33682 from Santa Cruz Biotechnology
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Anti-IREB2 antibody - ab169278 from Abcam
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Anti-IREB2 antibody - ab112574 from Abcam
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Anti-IREB2 antibody [EPR13854] - ab181153 from Abcam
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Anti-IREB2 / IRP2 Antibody (aa100-200) IHC-plus⢠- LS-B48 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (aa201-230) - LS-C165285 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (aa1-100) IHC-plus⢠- LS-B675 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (aa489-503) IHC-plus⢠- LS-B4397 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus) - LS-C16082 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus) - LS-C71088 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (Internal) - LS-C71089 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus) - LS-C16083 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus, Biotin) - LS-C140861 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody - LS-C130302 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus, DY650) - LS-C140862 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus, DY550) - LS-C140865 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus, DY488) - LS-C140863 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (N-Terminus, HRP) - LS-C140864 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (Internal, Biotin) - LS-C140866 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (Internal, DY650) - LS-C140867 from LifeSpan Bioscience
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Anti-IREB2 / IRP2 Antibody (Internal, HRP) - LS-C140869 from LifeSpan Bioscience
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