| Gene Symbol |
IREB2
|
| Entrez Gene |
3658
|
| Alt Symbol |
ACO3, IRP2, IRP2AD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
iron-responsive element binding protein 2
|
| Other Description |
IRE-BP 2|iron regulatory protein 2|iron-responsive element-binding protein 2
|
| Swissprots |
Q9UF17 Q8WVK6 H0YKU0 P48200 Q13095 Q1HE21 A8KAC7 E1CJT9 Q59FQ7
|
| Accessions |
ABF47091 EAW99169 EAW99170 EAW99171 P48200 AB209403 BAD92640 AB586699 BAJ19024 AK027033 AK027034 AK292992 BAF85681 AL117613 AL133439 CAB62825 BC017880 AAH17880 BC117481 AAI17482 BC117483 AAI17484 BC143948 BX340905 CN290278 HQ258663 ADR83414 M58511 AAA69901 U20180 AAA79926 NM_004136 NP_004127
|
| Function |
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}.
|
| Subcellular Location |
Cytoplasm.
|