Gene Symbol | IREB2 |
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Entrez Gene | 3658 |
Alt Symbol | ACO3, IRP2, IRP2AD |
Species | Human |
Gene Type | protein-coding |
Description | iron-responsive element binding protein 2 |
Other Description | IRE-BP 2|iron regulatory protein 2|iron-responsive element-binding protein 2 |
Swissprots | Q9UF17 Q8WVK6 H0YKU0 P48200 Q13095 Q1HE21 A8KAC7 E1CJT9 Q59FQ7 |
Accessions | ABF47091 EAW99169 EAW99170 EAW99171 P48200 AB209403 BAD92640 AB586699 BAJ19024 AK027033 AK027034 AK292992 BAF85681 AL117613 AL133439 CAB62825 BC017880 AAH17880 BC117481 AAI17482 BC117483 AAI17484 BC143948 BX340905 CN290278 HQ258663 ADR83414 M58511 AAA69901 U20180 AAA79926 NM_004136 NP_004127 |
Function | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}. |
Subcellular Location | Cytoplasm. |
Human IREB2 full length protein - ab152479 from Abcam
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IREB2 / IRP2 Antibody Blocking Peptide - LS-E1845 from LifeSpan Bioscience
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IREB2 / IRP2 Antibody Blocking Peptide - LS-E14793 from LifeSpan Bioscience
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IREB2 / IRP2 Antibody Blocking Peptide - LS-E27113 from LifeSpan Bioscience
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IRP2 Recombinant Protein - H00003658-P01 from Novus Biologicals
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IREB2-Antibody-Center-Blocking-peptide - BP12657c from Abgent, a WuXi AppTec company
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IREB2 blocking peptide - GTX88335-PEP from GeneTex
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IREB2 Immunizing peptide - orb59595 from Biorbyt
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IREB2 Blocking Peptide - 33R-4113 from Fitzgerald
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IREB2 Peptide - AC21-1933-P from Abcore
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IREB2 - H00003658-P01-10 from Acris Antibodies
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IREB2 - H00003658-P01-25 from Acris Antibodies
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IREB2 Peptide - 42-103P from ProSci
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IREB2 fusion protein - ag20653 from Proteintech Group
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IREB2 fusion protein - ag5710 from Proteintech Group
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Recombinant Iron Responsive Element Binding Protein 2 (IREB2) - RPH789Hu01 from Uscn Life Science Inc.
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Recombinant Iron Responsive Element Binding Protein 2 (IREB2) - RPH789Ra01 from Uscn Life Science Inc.
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Recombinant Iron Responsive Element Binding Protein 2 (IREB2) - RPH789Hu01 from Cloud-clone
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Recombinant Human Iron-responsive element-binding protein 2(IREB2) ,partial - CSB-YP011813HU CSB-EP011813HU CSB-BP011813HU CSB-MP011813HU from Cusabio
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IREB2 - TP321385 from Acris Antibodies
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IREB2/IRP2, Peptide - MBS425450 from MyBioSource
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IRP2 Recombinant Protein Antigen - NBP2-49576PEP from Novus Biologicals
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IREB2 Peptide, Human - M34GP07734H from Creative Peptides
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IREB2 Recombinant Protein (OPCD04525) - OPCD04525 from Aviva Systems Biology
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IRP2 Recombinant Protein Antigen - NBP2-55039PEP from Novus Biologicals
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