BCAR1

Gene Symbol	BCAR1
Entrez Gene	9564
Alt Symbol	CAS, CAS1, CASS1, CRKAS, P130Cas
Species	Human
Gene Type	protein-coding
Description	breast cancer anti-estrogen resistance 1
Other Description	Cas scaffolding protein family member 1|Crk-associated substrate p130Cas|breast cancer anti-estrogen resistance protein 1
Swissprots	F5H7Z0 B7Z7X7 B4DEV4 Q6QEF7 B3KWD7 B4DIW5 F8WA69 E9PCL5 F5GXV6 B4DGB5 F5GXA2 P56945 E9PCV2
Accessions	EAW95651 EAW95652 EAW95653 EAW95654 EAW95655 EAW95656 P56945 AB040024 BAA92711 AF218451 AAF27527 AJ242987 CAB75875 AK026121 AK027608 BAB55230 AK074958 BAC11315 AK124526 BAG54047 AK124815 BAG54099 AK124844 BAG54104 AK125719 BAG54238 AK127004 AK293808 BAG57215 AK294513 BAG57726 AK295809 BAG58627 AK302617 BAH13763 AK314722 BAG37266 AY545071 AAS48631 BC014402 AAH14402 BC062556 AAH62556 BU730553 DA418642 DC310094 DC317947 EU831404 ACE87091 EU831496 ACE86415 XM_005256258 XP_005256315 XM_005256259 XP_005256316 XM_005256260 XP_005256317 XM_011523473 XP_011521775 XM_011523474 XP_011521776 XM_011523475 XP_011521777 NM_001170714 NP_001164185 NM_001170715 NP_001164186 NM_001170716 NP_001164187 NM_001170717 NP_001164188 NM_001170718 NP_001164189 NM_001170719 NP_001164190 NM_001170720 NP_001164191 NM_001170721 NP_001164192 NM_014567 NP_055382
Function	Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. {ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
Subcellular Location	Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.
Tissue Specificity	Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Top Pathways	Focal adhesion, Leukocyte transendothelial migration, Chemokine signaling pathway, Bacterial invasion of epithelial cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-BCAR1 / p130Cas (Tyr410) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1091 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78.13-5000 pg/ml

Mouse/Human/Rat Phospho-BCAR1 / p130Cas (Tyr165) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1266 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78.13-5000 pg/ml

Mouse/Human/Rat Phospho-BCAR1 / p130Cas (Tyr249) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1267 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78.13-5000 pg/ml

Mouse/Human/Rat BCAR1 / p130Cas ELISA Kit (Cell-Based ELISA) - LS-F1821 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 78.13-5000 pg/ml

Human BCAR1 / p130Cas ELISA Kit (Sandwich ELISA) - LS-F7559 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 27 pg/ml Range 78.13-5000 pg/ml

Human BCAR1 ELISA Kit - abx150792 from Abbexa Category ELISA Kit Sensitivity 0.053 ng/ml Range 0.156 ng/ml - 10 ng/ml

Breast Cancer Anti Estrogen Resistance 1, BCAR1, Human, ELISA Kit - E-EL-H2383 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Breast cancer anti-estrogen resistance protein 1 (BCAR1), Human, ELISA Kit - E01B0755 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Breast Cancer Anti Estrogen Resistance 1, BCAR1, Rabbit, ELISA Kit - E-EL-RB1170 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Breast Cancer Anti Estrogen Resistance 1, BCAR1, Porcine, ELISA Kit - E-EL-P1752 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Breast Cancer Anti Estrogen Resistance 1, BCAR1, Sheep, ELISA Kit - E-EL-S0731 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Breast Cancer Anti Estrogen Resistance 1, BCAR1, Monkey, ELISA Kit - E-EL-MK1385 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

BCAR1 (Human) Matched Antibody Pair - H00009564-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Catalase Activity Kit - SKT-215 from StressMarq Bioscience Prices $385.00 Sizes 2 x 96 well Sensitivity 0.052 U/ml Range 0.156 - 5 U/ml

BCAR1 Colorimetric Cell-Based ELISA Kit - CB5067 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

BCAR1 (Phospho-Tyr410) Colorimetric Cell-Based ELISA Kit - CBP1070 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

BCAR1 (Phospho-Tyr165) Colorimetric Cell-Based ELISA Kit - CBP1266 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

BCAR1 (Phospho-Tyr249) Colorimetric Cell-Based ELISA Kit - CBP1267 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human BCAR1(Breast Cancer Anti Estrogen Resistance 1) ELISA Kit - E-EL-H2383 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human BCAR1 (Breast Cancer Anti Estrogen Resistance 1) CLIA Kit - E-CL-H1388 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

BCAR1, ELISA Kit - MBS2500184 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

BCAR1, ELISA Kit - MBS2514008 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

BCAR1, ELISA Kit - MBS2509707 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

BCAR1, ELISA Kit - MBS2503856 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

BCAR1, ELISA Kit - MBS2507198 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

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