| Gene Symbol | BCAR1 |
|---|---|
| Entrez Gene | 9564 |
| Alt Symbol | CAS, CAS1, CASS1, CRKAS, P130Cas |
| Species | Human |
| Gene Type | protein-coding |
| Description | breast cancer anti-estrogen resistance 1 |
| Other Description | Cas scaffolding protein family member 1|Crk-associated substrate p130Cas|breast cancer anti-estrogen resistance protein 1 |
| Swissprots | F5H7Z0 B7Z7X7 B4DEV4 Q6QEF7 B3KWD7 B4DIW5 F8WA69 E9PCL5 F5GXV6 B4DGB5 F5GXA2 P56945 E9PCV2 |
| Accessions | EAW95651 EAW95652 EAW95653 EAW95654 EAW95655 EAW95656 P56945 AB040024 BAA92711 AF218451 AAF27527 AJ242987 CAB75875 AK026121 AK027608 BAB55230 AK074958 BAC11315 AK124526 BAG54047 AK124815 BAG54099 AK124844 BAG54104 AK125719 BAG54238 AK127004 AK293808 BAG57215 AK294513 BAG57726 AK295809 BAG58627 AK302617 BAH13763 AK314722 BAG37266 AY545071 AAS48631 BC014402 AAH14402 BC062556 AAH62556 BU730553 DA418642 DC310094 DC317947 EU831404 ACE87091 EU831496 ACE86415 XM_005256258 XP_005256315 XM_005256259 XP_005256316 XM_005256260 XP_005256317 XM_011523473 XP_011521775 XM_011523474 XP_011521776 XM_011523475 XP_011521777 NM_001170714 NP_001164185 NM_001170715 NP_001164186 NM_001170716 NP_001164187 NM_001170717 NP_001164188 NM_001170718 NP_001164189 NM_001170719 NP_001164190 NM_001170720 NP_001164191 NM_001170721 NP_001164192 NM_014567 NP_055382 |
| Function | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. {ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| Subcellular Location | Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}. |
| Tissue Specificity | Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line. |
| Top Pathways | Focal adhesion, Leukocyte transendothelial migration, Chemokine signaling pathway, Bacterial invasion of epithelial cells, Rap1 signaling pathway |