BCAR1

Gene Symbol	BCAR1
Entrez Gene	9564
Alt Symbol	CAS, CAS1, CASS1, CRKAS, P130Cas
Species	Human
Gene Type	protein-coding
Description	breast cancer anti-estrogen resistance 1
Other Description	Cas scaffolding protein family member 1|Crk-associated substrate p130Cas|breast cancer anti-estrogen resistance protein 1
Swissprots	F5H7Z0 B7Z7X7 B4DEV4 Q6QEF7 B3KWD7 B4DIW5 F8WA69 E9PCL5 F5GXV6 B4DGB5 F5GXA2 P56945 E9PCV2
Accessions	EAW95651 EAW95652 EAW95653 EAW95654 EAW95655 EAW95656 P56945 AB040024 BAA92711 AF218451 AAF27527 AJ242987 CAB75875 AK026121 AK027608 BAB55230 AK074958 BAC11315 AK124526 BAG54047 AK124815 BAG54099 AK124844 BAG54104 AK125719 BAG54238 AK127004 AK293808 BAG57215 AK294513 BAG57726 AK295809 BAG58627 AK302617 BAH13763 AK314722 BAG37266 AY545071 AAS48631 BC014402 AAH14402 BC062556 AAH62556 BU730553 DA418642 DC310094 DC317947 EU831404 ACE87091 EU831496 ACE86415 XM_005256258 XP_005256315 XM_005256259 XP_005256316 XM_005256260 XP_005256317 XM_011523473 XP_011521775 XM_011523474 XP_011521776 XM_011523475 XP_011521777 NM_001170714 NP_001164185 NM_001170715 NP_001164186 NM_001170716 NP_001164187 NM_001170717 NP_001164188 NM_001170718 NP_001164189 NM_001170719 NP_001164190 NM_001170720 NP_001164191 NM_001170721 NP_001164192 NM_014567 NP_055382
Function	Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. {ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
Subcellular Location	Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.
Tissue Specificity	Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Top Pathways	Focal adhesion, Leukocyte transendothelial migration, Chemokine signaling pathway, Bacterial invasion of epithelial cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BCAR1 peptide - ab89387 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human BCAR1 full length protein - ab132142 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human BCAR1 protein fragment - ab152999 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human BCAR1 protein fragment - ab177668 from Abcam Category Protein Prices $400.00 Sizes 50 µg Source E. coli Species Human

BCAR1 / p130Cas Antibody Blocking Peptide - LS-E23107 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

p130Cas/BCAR1 Recombinant Protein - H00009564-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p130Cas/BCAR1 Partial Recombinant Protein - H00009564-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BCAR1-Antibody-C-term-Blocking-peptide - BP10123b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

p130cas-Antibody-Center-Y224-Blocking-peptide - BP12200c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BCAR1 peptide - orb218268 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

BCAR1 protein (His tag) - 80R-3671 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

BCAR1 Peptide - AC21-2976-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

BCAR1 / CRKAS (465-848, His-tag) - AR51358PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

BCAR1 / CRKAS (465-848, His-tag) - AR51358PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

BCAR1 / CRKAS - H00009564-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

BCAR1 / CRKAS - H00009564-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BCAR1 / CRKAS - H00009564-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BCAR1 / CRKAS - H00009564-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BCAR1, 465-848aa, Human, His tag, E.coli - 01-P2538 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

BCAR1 fusion protein - ag10354 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

BCAR1 fusion protein - Ag10604 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human BCAR1, His-tagged - BCAR1-5042H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human breast cancer anti-estrogen resistance 1, His-tagged - BCAR1-441H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) - RPG769Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

p130 Cas (pY249) Blocking Peptide - CBP2405 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

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