BCAR1

Gene Symbol BCAR1
Entrez Gene 9564
Alt Symbol CAS, CAS1, CASS1, CRKAS, P130Cas
Species Human
Gene Type protein-coding
Description breast cancer anti-estrogen resistance 1
Other Description Cas scaffolding protein family member 1|Crk-associated substrate p130Cas|breast cancer anti-estrogen resistance protein 1
Swissprots F5H7Z0 B7Z7X7 B4DEV4 Q6QEF7 B3KWD7 B4DIW5 F8WA69 E9PCL5 F5GXV6 B4DGB5 F5GXA2 P56945 E9PCV2
Accessions EAW95651 EAW95652 EAW95653 EAW95654 EAW95655 EAW95656 P56945 AB040024 BAA92711 AF218451 AAF27527 AJ242987 CAB75875 AK026121 AK027608 BAB55230 AK074958 BAC11315 AK124526 BAG54047 AK124815 BAG54099 AK124844 BAG54104 AK125719 BAG54238 AK127004 AK293808 BAG57215 AK294513 BAG57726 AK295809 BAG58627 AK302617 BAH13763 AK314722 BAG37266 AY545071 AAS48631 BC014402 AAH14402 BC062556 AAH62556 BU730553 DA418642 DC310094 DC317947 EU831404 ACE87091 EU831496 ACE86415 XM_005256258 XP_005256315 XM_005256259 XP_005256316 XM_005256260 XP_005256317 XM_011523473 XP_011521775 XM_011523474 XP_011521776 XM_011523475 XP_011521777 NM_001170714 NP_001164185 NM_001170715 NP_001164186 NM_001170716 NP_001164187 NM_001170717 NP_001164188 NM_001170718 NP_001164189 NM_001170719 NP_001164190 NM_001170720 NP_001164191 NM_001170721 NP_001164192 NM_014567 NP_055382
Function Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. {ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
Subcellular Location Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.
Tissue Specificity Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Top Pathways Focal adhesion, Leukocyte transendothelial migration, Chemokine signaling pathway, Bacterial invasion of epithelial cells, Rap1 signaling pathway

Phospho-p130 Cas (Tyr249) Antibody - 4014 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3 cells, untreated or calf intestinal phosphatase (CIP)-treated, using Phospho-p130Cas (Tyr249) Antibody (upper) or p130Cas antibody (lower).

Phospho-p130 Cas (Tyr165) Antibody - 4015 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH-3T3 cells, untreated or calf intestinal phosphotase (CIP)-treated, using Phospho-p130 Cas (Tyr165) Antibody (upper) or p130 Cas antibody (lower).

Phospho-p130 Cas (Tyr410) Antibody - 4011 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3 cells, untreated or calf intestinal phosphotase (CIP)-treated, using Phospho-p130Cas (Tyr410) Antibody (upper) or p130Cas antibody (lower).

p130 Cas (E1L9H) Rabbit mAb - 13846 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1L9H
Western blot analysis of extracts from various cell lines using p130 Cas (E1L9H) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

p130 Cas (E1L9G) Rabbit mAb - 13383 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1L9G
Western blot analysis of extracts from various cell lines using p130 Cas (E1L9G) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

p130 Cas Antibody - 12015 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

p130 (H-125) - sc-20678 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p130 (H-125): sc-20678. Western blot analysis of human recombinant p130 fusion protein.

p130 Cas (35B.1A4) - sc-20029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 Cas (35B.1A4): sc-20029. Immunofluorescence staining of methanol-fixed BJAB cells (A) and immuno-peroxidase staining of formalin-fixed, paraffin-embedded human breast tumor (B) showing cytoplasmic staining.

p130 Cas (C-4) - sc-365200 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 Cas (C-4): sc-365200. Western blot analysis of p130 Cas expression in non-transfected: sc-117752 (A) and human p130 Cas transfected: sc-177673 (B) 293T whole cell lysates.

p130 Cas (M-72) - sc-9052 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p130 Cas (M-72): sc-9052. Western blot analysis of p130 Cas expression in HeLa whole cell lysate.

p130 Cas (N-20) - sc-16516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p130 Cas (N-20): sc-16516. Western blot analysis of p130 Cas expression in KNRK whole cell lysate.

p130 Cas (C-20) - sc-860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p130 Cas (C-20): sc-860. Western blot analysis of p130 Cas expression in 3611-RF whole cell lysate.

p130 Cas (S-20) - sc-16517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p130 Cas (S-20): sc-16517. Western blot analysis of p130 Cas expression in IMR-32 (A) and KNRK (B) whole cell lysates.

p130 Cas (SPM302) - sc-65517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 Cas (SPM302): sc-65517. Western blot analysis of p130 Cas expression in non-transfected: sc-117752 (A) and human p130 Cas transfected: sc-177673 (B) 293T whole cell lysates.

p130 Cas (3F309) - sc-71796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p130 Cas/Sin (N-17) - sc-859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p130 Cas/Sin (N-17): sc-859. Western blot analysis of p130 Cas expression in 3611-RF whole cell lysate.

Anti-BCAR1 (phospho Y165) antibody - ab60989 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human breast carcinoma tissue stained with ab60989 at 1/50 dilution, in the presence (right) or absence(left) of the immunizing phosphopeptide.

Anti-BCAR1 (phospho Y249) antibody - ab63360 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of BCAR1 expression in paraffin-embedded human breast carcinoma tissue using 1/50 ab63360. Left image: untreated. Right image: sample treated with immunising peptide.

Anti-BCAR1 (phospho Y410) antibody - ab55263 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BCAR1 (phospho Y410) antibody (ab55263) at 1/500 dilutionLane 1 : extracts from NIH/3T3 cells.Lane 2 : extracts from NIH/3T3 cells, incubated with the immunising phosphopeptide.

Anti-BCAR1 (phospho Y410) antibody - ab138410 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BCAR1 (phospho Y410) antibody (ab138410) at 1/500 dilution + HepG2 cell extracts, treated with EGF at 30 µg

Anti-BCAR1 (phospho Y410) antibody [EPR1860] - ab92699 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1860
All lanes : Anti-BCAR1 (phospho Y410) antibody [EPR1860] (ab92699) at 1/2500 dilutionLane 1 : HeLa cell lysate untreatedLane 2 : HeLa cell lysate treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP-labeled goat anti-rabbit at 1/2000 dilution

Anti-BCAR1 (phospho Y751) antibody - ab45486 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : anti-p130 CasLanes 3 - 4 : Anti-BCAR1 (phospho Y751) antibody (ab45486) at 1/2000 dilutionLanes 5 - 6 : anti-p130 Cas (Tyr-762)Lane 1 : human endothelial cells serum starved overnightLane 2 : human endothelial cells treated with pervanadate (1 mM) for 30 minutesLane 3 : human endothelial cells serum starved overnightLane 4 : human endothelial cells treated with pervanadate (1 mM) for 30 minutesLane 5 : human endothelial cells serum starved overnightLane 6 : human endothelial cells treated with pervanadate (1 mM) for 30 minutes

Anti-BCAR1 (phospho Y762) antibody - ab41827 from Abcam

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BCAR1 antibody - ab52198 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Paraffin-embedded human breast carcinoma tissue stained for BCAR1, using ab52198 (1/50). The right-hand panel represents a negative control where ab52198 was pre-incubated with the immunizing (blocking) peptide.

Anti-BCAR1 antibody - ab14979 from Abcam

Prices $372.00
Sizes 125 µg
Host Rabbit
Clonality Polyclonal
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