BCAR1

Gene Symbol BCAR1
Entrez Gene 9564
Alt Symbol CAS, CAS1, CASS1, CRKAS, P130Cas
Species Human
Gene Type protein-coding
Description breast cancer anti-estrogen resistance 1
Other Description Cas scaffolding protein family member 1|Crk-associated substrate p130Cas|breast cancer anti-estrogen resistance protein 1
Swissprots F5H7Z0 B7Z7X7 B4DEV4 Q6QEF7 B3KWD7 B4DIW5 F8WA69 E9PCL5 F5GXV6 B4DGB5 F5GXA2 P56945 E9PCV2
Accessions EAW95651 EAW95652 EAW95653 EAW95654 EAW95655 EAW95656 P56945 AB040024 BAA92711 AF218451 AAF27527 AJ242987 CAB75875 AK026121 AK027608 BAB55230 AK074958 BAC11315 AK124526 BAG54047 AK124815 BAG54099 AK124844 BAG54104 AK125719 BAG54238 AK127004 AK293808 BAG57215 AK294513 BAG57726 AK295809 BAG58627 AK302617 BAH13763 AK314722 BAG37266 AY545071 AAS48631 BC014402 AAH14402 BC062556 AAH62556 BU730553 DA418642 DC310094 DC317947 EU831404 ACE87091 EU831496 ACE86415 XM_005256258 XP_005256315 XM_005256259 XP_005256316 XM_005256260 XP_005256317 XM_011523473 XP_011521775 XM_011523474 XP_011521776 XM_011523475 XP_011521777 NM_001170714 NP_001164185 NM_001170715 NP_001164186 NM_001170716 NP_001164187 NM_001170717 NP_001164188 NM_001170718 NP_001164189 NM_001170719 NP_001164190 NM_001170720 NP_001164191 NM_001170721 NP_001164192 NM_014567 NP_055382
Function Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. {ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
Subcellular Location Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.
Tissue Specificity Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Top Pathways Focal adhesion, Leukocyte transendothelial migration, Chemokine signaling pathway, Bacterial invasion of epithelial cells, Rap1 signaling pathway

p130 Cas CRISPR/Cas9 KO Plasmid (h) - sc-401562 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas HDR Plasmid (h) - sc-401562-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas Double Nickase Plasmid (h) - sc-401562-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas Double Nickase Plasmid (h2) - sc-401562-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas CRISPR Activation Plasmid (h) - sc-401562-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas CRISPR Activation Plasmid (h2) - sc-401562-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas Lentiviral Activation Particles (h) - sc-401562-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas Lentiviral Activation Particles (h2) - sc-401562-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p130 Cas siRNA (h) - sc-36141 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p130 Cas shRNA Plasmid (h) - sc-36141-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p130 Cas shRNA (h) Lentiviral Particles - sc-36141-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p130 Cas siRNA (h2) - sc-44317 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p130 Cas shRNA Plasmid (h2) - sc-44317-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p130 Cas shRNA (h2) Lentiviral Particles - sc-44317-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p130Cas/BCAR1 RNAi - H00009564-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU142941 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3890 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3890 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05566 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05566

BCAR1 siRNA (Human) - CRH6363 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCAR1 - MBS8226815 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BCAR1 (NM_014567.3) - SHH245682 from Creative biogene

Category siRNA
Species Reactivities Human

Human BCAR1 siRNA - orb266865 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCAR1 shRNA Plasmid (Human) - CHH6363 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BCAR1 miRNA 3'UTR clone - MiUTR3H-05431 from Creative biogene

Species Reactivities Human
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