| Gene Symbol |
DLGAP5
|
| Entrez Gene |
9787
|
| Alt Symbol |
DLG7, HURP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
discs, large (Drosophila) homolog-associated protein 5
|
| Other Description |
DAP-5|discs large homolog 7|discs, large homolog 7|disks large-associated protein 5|disks large-associated protein DLG7|hepatoma up-regulated protein
|
| Swissprots |
B4DRM8 Q86T11 A8MTM6 Q15398 Q8NG58
|
| Accessions |
CBJ05774 CBJ21226 EAW80662 EAW80663 EAW80664 Q15398 AB076695 BAB97376 AI174844 AK291847 BAF84536 AK297480 BAG59901 AK299338 BAG61340 BC010658 AAH10658 BC016276 AAH16276 BM788630 BT007344 AAP36008 BX248255 CAD62583 D13633 BAA02797 DB448424 DB451654 XM_011537414 XP_011535716 XR_943566 NM_001146015 NP_001139487 NM_014750 NP_055565
|
| Function |
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
|
| Tissue Specificity |
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. {ECO:0000269|PubMed:12527899}.
|
![Western Blot: DLG7/HURP Overexpression Lysate (Adult Normal) [NBP2-10306] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DLG7/HURP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1242_DLG7-HURP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10306-img0001.jpg)