Gene Symbol | DLGAP5 |
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Entrez Gene | 9787 |
Alt Symbol | DLG7, HURP |
Species | Human |
Gene Type | protein-coding |
Description | discs, large (Drosophila) homolog-associated protein 5 |
Other Description | DAP-5|discs large homolog 7|discs, large homolog 7|disks large-associated protein 5|disks large-associated protein DLG7|hepatoma up-regulated protein |
Swissprots | B4DRM8 Q86T11 A8MTM6 Q15398 Q8NG58 |
Accessions | CBJ05774 CBJ21226 EAW80662 EAW80663 EAW80664 Q15398 AB076695 BAB97376 AI174844 AK291847 BAF84536 AK297480 BAG59901 AK299338 BAG61340 BC010658 AAH10658 BC016276 AAH16276 BM788630 BT007344 AAP36008 BX248255 CAD62583 D13633 BAA02797 DB448424 DB451654 XM_011537414 XP_011535716 XR_943566 NM_001146015 NP_001139487 NM_014750 NP_055565 |
Function | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells. |
Tissue Specificity | Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. {ECO:0000269|PubMed:12527899}. |
HURP CRISPR/Cas9 KO Plasmid (h) - sc-402206 from Santa Cruz Biotechnology
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HURP HDR Plasmid (h) - sc-402206-HDR from Santa Cruz Biotechnology
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HURP Double Nickase Plasmid (h) - sc-402206-NIC from Santa Cruz Biotechnology
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HURP Double Nickase Plasmid (h2) - sc-402206-NIC-2 from Santa Cruz Biotechnology
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HURP CRISPR Activation Plasmid (h) - sc-402206-ACT from Santa Cruz Biotechnology
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HURP CRISPR Activation Plasmid (h2) - sc-402206-ACT-2 from Santa Cruz Biotechnology
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HURP Lentiviral Activation Particles (h) - sc-402206-LAC from Santa Cruz Biotechnology
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HURP Lentiviral Activation Particles (h2) - sc-402206-LAC-2 from Santa Cruz Biotechnology
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HURP siRNA (h) - sc-75316 from Santa Cruz Biotechnology
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HURP shRNA Plasmid (h) - sc-75316-SH from Santa Cruz Biotechnology
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HURP shRNA (h) Lentiviral Particles - sc-75316-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU064731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7293 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7293 from Sigma-Aldrich
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DLGAP5 siRNA (Human) - CRH6549 from Cohesion Biosciences
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DLGAP5 - MBS8220417 from MyBioSource
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shRNA set against Human DLGAP5 (NM_014750.4) - SHH278585 from Creative biogene
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DLGAP5 shRNA Plasmid (Human) - CHH6549 from Cohesion Biosciences
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DLGAP5 miRNA 3'UTR clone - MiUTR3H-14570 from Creative biogene
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DLGAP5 miRNA 3'UTR clone - MiUTR3H-14571 from Creative biogene
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