| Gene Symbol | LIG4 |
|---|---|
| Entrez Gene | 3981 |
| Alt Symbol | LIG4S |
| Species | Human |
| Gene Type | protein-coding |
| Description | ligase IV, DNA, ATP-dependent |
| Other Description | DNA joinase|DNA ligase 4|DNA ligase IV|DNA repair enzyme|polydeoxyribonucleotide synthase [ATP] 4|polynucleotide ligase|sealase |
| Swissprots | Q8TEU5 P49917 Q8IY66 |
| Accessions | AAL77435 EAX09094 EAX09095 EAX09096 P49917 AI809944 AK292419 BAF85108 AK314844 BAG37361 BC037491 AAH37491 BX648833 CD102896 DQ892474 ABM83400 DQ895686 ABM86612 X83441 CAA58467 XM_005254056 XP_005254113 XM_005254057 XP_005254114 XM_005254058 XP_005254115 XM_006719951 XP_006720014 XM_006719952 XP_006720015 XM_011521091 XP_011519393 XM_011521092 XP_011519394 NM_001098268 NP_001091738 NM_002312 NP_002303 NM_206937 NP_996820 |
| Function | Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:9809069}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Testis, thymus, prostate and heart. |
| Top Pathways | Non-homologous end-joining |