| Gene Symbol |
LIG4
|
| Entrez Gene |
3981
|
| Alt Symbol |
LIG4S
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ligase IV, DNA, ATP-dependent
|
| Other Description |
DNA joinase|DNA ligase 4|DNA ligase IV|DNA repair enzyme|polydeoxyribonucleotide synthase [ATP] 4|polynucleotide ligase|sealase
|
| Swissprots |
Q8TEU5 P49917 Q8IY66
|
| Accessions |
AAL77435 EAX09094 EAX09095 EAX09096 P49917 AI809944 AK292419 BAF85108 AK314844 BAG37361 BC037491 AAH37491 BX648833 CD102896 DQ892474 ABM83400 DQ895686 ABM86612 X83441 CAA58467 XM_005254056 XP_005254113 XM_005254057 XP_005254114 XM_005254058 XP_005254115 XM_006719951 XP_006720014 XM_006719952 XP_006720015 XM_011521091 XP_011519393 XM_011521092 XP_011519394 NM_001098268 NP_001091738 NM_002312 NP_002303 NM_206937 NP_996820
|
| Function |
Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:9809069}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Testis, thymus, prostate and heart.
|
| Top Pathways |
Non-homologous end-joining
|
![Western Blot: DNA Ligase IV Overexpression Lysate (Adult Normal) [NBL1-12521] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNA Ligase IV.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6288_DNA%2520Ligase%2520IV%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12521-img0002.jpg)
![Western Blot: DNA Ligase IV Overexpression Lysate (Adult Normal) [NBP2-11429] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNA Ligase IV.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2565_DNA%2520Ligase%2520IV%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11429-img0001.jpg)