LIG4

Gene Symbol	LIG4
Entrez Gene	3981
Alt Symbol	LIG4S
Species	Human
Gene Type	protein-coding
Description	ligase IV, DNA, ATP-dependent
Other Description	DNA joinase|DNA ligase 4|DNA ligase IV|DNA repair enzyme|polydeoxyribonucleotide synthase [ATP] 4|polynucleotide ligase|sealase
Swissprots	Q8TEU5 P49917 Q8IY66
Accessions	AAL77435 EAX09094 EAX09095 EAX09096 P49917 AI809944 AK292419 BAF85108 AK314844 BAG37361 BC037491 AAH37491 BX648833 CD102896 DQ892474 ABM83400 DQ895686 ABM86612 X83441 CAA58467 XM_005254056 XP_005254113 XM_005254057 XP_005254114 XM_005254058 XP_005254115 XM_006719951 XP_006720014 XM_006719952 XP_006720015 XM_011521091 XP_011519393 XM_011521092 XP_011519394 NM_001098268 NP_001091738 NM_002312 NP_002303 NM_206937 NP_996820
Function	Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:9809069}.
Subcellular Location	Nucleus.
Tissue Specificity	Testis, thymus, prostate and heart.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LIG4 - MBS1267837 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC037491

Human LIG4 cDNA clone(NM_206937.1) - CDFG013689 from Creative Biomart

Human LIG4 cDNA clone(NM_001098268.1) - CDFH010373 from Creative Biomart Species Human Accession NM_001098268.1

Human LIG4 cDNA clone(NM_002312.3) - CDFH010374 from Creative Biomart Species Human Accession NM_002312.3

Human LIG4 ORF Clone(NM_001098268.1) - CDCL168658 from Creative Biomart Species Human Accession NM_001098268.1

Human LIG4 ORF Clone(NM_002312.3) - CDCR282937 from Creative Biomart Species Human Accession NM_002312.3

Human LIG4 ORF Clone(NM_002312.3) - CDCR282938 from Creative Biomart Species Human Accession NM_002312.3

Human LIG4 ORF Clone(NM_002312.3) - CDCR282939 from Creative Biomart Species Human Accession NM_002312.3

Human LIG4 ORF Clone(NM_206937.1) - CDCR327718 from Creative Biomart Species Human Accession NM_206937.1

Human LIG4 ORF Clone(NM_206937.1) - CDCR327719 from Creative Biomart Species Human Accession NM_206937.1

Human LIG4 ORF Clone(NM_206937.1) - CDCR327720 from Creative Biomart Species Human Accession NM_206937.1

Human LIG4 ORF Clone(NM_001098268.1) - CDCR346452 from Creative Biomart Species Human Accession NM_001098268.1

Human LIG4 ORF Clone(NM_001098268.1) - CDCR346453 from Creative Biomart Species Human Accession NM_001098268.1

Human LIG4/DNA Ligase IV Gene ORF cDNA clone in cloning vector - HG14422-G from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14422-ACR from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14422-ANR from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid - HG14422-UT from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, C-HA tag - HG14422-CY from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14422-NF from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14422-CF from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14422-NM from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, N-His tag - HG14422-NH from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14422-CM from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14422-ANG from Sino Biological Species Human

Human LIG4/DNA Ligase IV Gene ORF cDNA clone expression plasmid, N-HA tag - HG14422-NY from Sino Biological Species Human

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