LIG4

Gene Symbol	LIG4
Entrez Gene	3981
Alt Symbol	LIG4S
Species	Human
Gene Type	protein-coding
Description	ligase IV, DNA, ATP-dependent
Other Description	DNA joinase|DNA ligase 4|DNA ligase IV|DNA repair enzyme|polydeoxyribonucleotide synthase [ATP] 4|polynucleotide ligase|sealase
Swissprots	Q8TEU5 P49917 Q8IY66
Accessions	AAL77435 EAX09094 EAX09095 EAX09096 P49917 AI809944 AK292419 BAF85108 AK314844 BAG37361 BC037491 AAH37491 BX648833 CD102896 DQ892474 ABM83400 DQ895686 ABM86612 X83441 CAA58467 XM_005254056 XP_005254113 XM_005254057 XP_005254114 XM_005254058 XP_005254115 XM_006719951 XP_006720014 XM_006719952 XP_006720015 XM_011521091 XP_011519393 XM_011521092 XP_011519394 NM_001098268 NP_001091738 NM_002312 NP_002303 NM_206937 NP_996820
Function	Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:9809069}.
Subcellular Location	Nucleus.
Tissue Specificity	Testis, thymus, prostate and heart.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNA Ligase IV CRISPR/Cas9 KO Plasmid (h) - sc-401372 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV HDR Plasmid (h) - sc-401372-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV Double Nickase Plasmid (h) - sc-401372-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV Double Nickase Plasmid (h2) - sc-401372-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV CRISPR Activation Plasmid (h) - sc-401372-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV CRISPR Activation Plasmid (h2) - sc-401372-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV Lentiviral Activation Particles (h) - sc-401372-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV Lentiviral Activation Particles (h2) - sc-401372-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNA Ligase IV siRNA (h) - sc-37394 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNA Ligase IV shRNA Plasmid (h) - sc-37394-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNA Ligase IV shRNA (h) Lentiviral Particles - sc-37394-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNA Ligase IV RNAi - H00003981-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU062841 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1595 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN11705 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1595 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11705 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

LIG4 siRNA (Human) - CRH2694 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DNA Ligase IV RNAi - H00003981-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human LIG4 (NM_002312.3) - SHH330251 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human LIG4(NM_002312.3) - SHH149339 from Creative biogene Category siRNA Species Reactivities Human

Human LIG4 siRNA - orb263196 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

LIG4 shRNA Plasmid (Human) - CHH2694 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

LIG4 miRNA 3'UTR clone - MiUTR1H-05669 from Creative biogene Species Reactivities Human

LIG4 miRNA 3'UTR clone - MiUTR3H-04444 from Creative biogene Species Reactivities Human

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