LIG4

Gene Symbol	LIG4
Entrez Gene	3981
Alt Symbol	LIG4S
Species	Human
Gene Type	protein-coding
Description	ligase IV, DNA, ATP-dependent
Other Description	DNA joinase|DNA ligase 4|DNA ligase IV|DNA repair enzyme|polydeoxyribonucleotide synthase [ATP] 4|polynucleotide ligase|sealase
Swissprots	Q8TEU5 P49917 Q8IY66
Accessions	AAL77435 EAX09094 EAX09095 EAX09096 P49917 AI809944 AK292419 BAF85108 AK314844 BAG37361 BC037491 AAH37491 BX648833 CD102896 DQ892474 ABM83400 DQ895686 ABM86612 X83441 CAA58467 XM_005254056 XP_005254113 XM_005254057 XP_005254114 XM_005254058 XP_005254115 XM_006719951 XP_006720014 XM_006719952 XP_006720015 XM_011521091 XP_011519393 XM_011521092 XP_011519394 NM_001098268 NP_001091738 NM_002312 NP_002303 NM_206937 NP_996820
Function	Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:9809069}.
Subcellular Location	Nucleus.
Tissue Specificity	Testis, thymus, prostate and heart.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active T4 DNA Ligase full length protein - ab68649 from Abcam Category Protein Prices $279.00 Sizes 20000 units Source E. coli

Human DNA Ligase IV peptide - ab90599 from Abcam Category Peptide

Recombinant Human DNA Ligase IV Protein - H00003981-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LIG4 Blocking Peptide - 33R-1948 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNA Ligase 4 Blocking Peptide - abx062877 from Abbexa Category Peptide Species Human, Bovine, Dog

DNA ligase 4 - H00003981-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNA ligase 4 - H00003981-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LIG4 fusion protein - ag3385 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant T4 DNA Ligase - BP000728-ENZ-286 from Syd Labs Category Protein Prices $255.00, $990.00 Sizes 100,000 iu, 500,000 iu Source Escherichia Colilambda lysogen NM 989-derived.

Recombinant Human LIG4 protein, GST-tagged - LIG4-508H from Creative Biomart Category Protein Source Wheat Germ Species Human

DNA Ligase 4 Blocking Peptide - CBP1683 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Bovine, Dog

DNA Ligase IV (G619) Peptide - BS2234P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA ligase 4(LIG4) ,partial - CSB-YP012932HU CSB-EP012932HU CSB-BP012932HU CSB-MP012932HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant T4 DNA Ligase - CSI12682 from Cell Science Prices $150.00 Sizes 2 x 10e4 u

Recombinant T4 DNA Ligase - CSI12683 from Cell Science Prices $360.00 Sizes 1 x 10e5 u

Recombinant T4 DNA Ligase - CSI12684 from Cell Science Prices $1,900.00 Sizes 5 x 10e5 u

T4 DNA Ligase Recombinant - Pr22258 from ProMab Category Protein Prices $65.00, $255.00, $990.00 Sizes 20,000iu, 100,000iu, 500,000iu Source Escherichia Colilambda lysogen NM 989.

DNA Ligase IV Recombinant Protein Antigen - NBP1-87405PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA Ligase 4 Blocking Peptide - abx061782 from Abbexa Category Peptide

LIG4-Blocking-Peptide-N-term - BP20303a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LIG4 Peptide, Human - M34GP08699H from Creative Peptides Category Peptide Source Synthetic. Species Human

DNA Ligase 4 Blocking Peptide - CBP7172 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

DNA ligase 4 (LIG4), partial, Recombinant Protein - MBS951845 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

LIG4 peptide - orb217546 from Biorbyt Category Peptide Species Human, Dog

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