Gene Symbol | SLA2 |
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Entrez Gene | 84174 |
Alt Symbol | C20orf156, MARS, SLAP-2, SLAP2 |
Species | Human |
Gene Type | protein-coding |
Description | Src-like-adaptor 2 |
Other Description | Src-like adapter protein-2|modulator of antigen receptor signaling|src-like-adapter 2 |
Swissprots | Q8WY18 Q5TH28 A8K648 E1P5U2 E1P5U1 Q9H6Q3 Q96QI4 Q5TH27 Q9H135 |
Accessions | EAW76116 EAW76117 EAW76118 EAW76119 Q9H6Q3 AF290985 AAL38197 AF290986 AAL38198 AF326353 AAL29204 AK025645 BAB15201 AK291513 BAF84202 BC042041 AAH42041 BF062179 BF510664 BQ052468 DA983348 XM_005260572 XP_005260629 NM_032214 NP_115590 NM_175077 NP_778252 |
Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}. |
Subcellular Location | Isoform 2: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes. |
Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
SLA2 (53.50) - sc-135799 from Santa Cruz Biotechnology
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SLA2 (80.30) - sc-135800 from Santa Cruz Biotechnology
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SLA2 (E-2) - sc-398928 from Santa Cruz Biotechnology
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SLA2 (E-8) - sc-398134 from Santa Cruz Biotechnology
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SLA2 (E-18) - sc-85917 from Santa Cruz Biotechnology
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SLA2 (G-16) - sc-85918 from Santa Cruz Biotechnology
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SLA2 (W-13) - sc-85919 from Santa Cruz Biotechnology
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SLA2 (H-75) - sc-366097 from Santa Cruz Biotechnology
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SLA2 (5-RE27) - sc-135561 from Santa Cruz Biotechnology
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Anti-SLAP2 antibody - ab187136 from Abcam
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Anti-SLAP2 antibody - ab66060 from Abcam
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Anti-SLAP2 antibody - ab169171 from Abcam
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Anti-SLAP2 antibody [1F7] - ab131571 from Abcam
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Anti-SLAP2 antibody [3D4] - ab139303 from Abcam
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Anti-SLAP2 antibody [EPR8083(2)] - ab170918 from Abcam
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Anti-SLA2 / SLAP2 Antibody (aa66-115) - LS-C135810 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 3A7) - LS-C174152 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 2G3) - LS-C174159 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 3E3) - LS-C174150 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 1F7) - LS-C337825 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (aa1-262, Azide-free) - LS-C328751 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 1D2) - LS-C174151 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 3D4) - LS-C174185 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 3H9) - LS-C174191 from LifeSpan Bioscience
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Anti-SLA2 / SLAP2 Antibody (clone 1D8) - LS-C174133 from LifeSpan Bioscience
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