Gene Symbol | SLA2 |
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Entrez Gene | 84174 |
Alt Symbol | C20orf156, MARS, SLAP-2, SLAP2 |
Species | Human |
Gene Type | protein-coding |
Description | Src-like-adaptor 2 |
Other Description | Src-like adapter protein-2|modulator of antigen receptor signaling|src-like-adapter 2 |
Swissprots | Q8WY18 Q5TH28 A8K648 E1P5U2 E1P5U1 Q9H6Q3 Q96QI4 Q5TH27 Q9H135 |
Accessions | EAW76116 EAW76117 EAW76118 EAW76119 Q9H6Q3 AF290985 AAL38197 AF290986 AAL38198 AF326353 AAL29204 AK025645 BAB15201 AK291513 BAF84202 BC042041 AAH42041 BF062179 BF510664 BQ052468 DA983348 XM_005260572 XP_005260629 NM_032214 NP_115590 NM_175077 NP_778252 |
Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}. |
Subcellular Location | Isoform 2: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes. |
Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
Human SLAP2 full length protein - ab164516 from Abcam
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Human SLAP2 full length protein - ab174415 from Abcam
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MARS Antibody Blocking Peptide - LS-E11489 from LifeSpan Bioscience
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MARS Antibody Blocking Peptide - LS-E9307 from LifeSpan Bioscience
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SLA2 / SLAP2 Antibody Blocking Peptide - LS-E22142 from LifeSpan Bioscience
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SLA2 / SLAP2 Antibody Blocking Peptide - LS-E22143 from LifeSpan Bioscience
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SLA2 Recombinant Protein - H00084174-P01 from Novus Biologicals
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Recombinant Human Methionyl tRNA synthetase Protein - H00004141-P01 from Novus Biologicals
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Recombinant Human Methionyl tRNA synthetase Protein - H00004141-Q01 from Novus Biologicals
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Recombinant Human SLA2 Protein - NBP2-22823 from Novus Biologicals
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MARS Blocking Peptide - 33R-3311 from Fitzgerald
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SLA2 Blocking Peptide - 33R-3216 from Fitzgerald
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SLA2 Blocking Peptide - 33R-9975 from Fitzgerald
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SLA2 protein (His tag) - 80R-3607 from Fitzgerald
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SLA2 (1-261, His-tag) - AR51294PU-N from Acris Antibodies
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SLA2 (1-261, His-tag) - AR51294PU-S from Acris Antibodies
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SLA2 - H00084174-P01-10 from Acris Antibodies
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SLA2 - H00084174-P01-25 from Acris Antibodies
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SLA2, 1-261aa, Human, His tag, E.coli - 01-P2474 from ARP American Research Products
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SLA2 fusion protein - ag5334 from Proteintech Group
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SLA2 fusion protein - ag5830 from Proteintech Group
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Recombinant human SLA2, His-tagged - SLA2-2474H from Creative Biomart
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Recombinant Human SLA2, GST-tagged - SLA2-2692H from Creative Biomart
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Recombinant Human Src-like-adapter 2(SLA2) - CSB-YP880986HU CSB-EP880986HU CSB-BP880986HU CSB-MP880986HU from Cusabio
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SLA2, 1-261aa, Human, His tag, E.coli (Denatured) - ATGP2474 from ATGen
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