Gene Symbol | SLA2 |
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Entrez Gene | 84174 |
Alt Symbol | C20orf156, MARS, SLAP-2, SLAP2 |
Species | Human |
Gene Type | protein-coding |
Description | Src-like-adaptor 2 |
Other Description | Src-like adapter protein-2|modulator of antigen receptor signaling|src-like-adapter 2 |
Swissprots | Q8WY18 Q5TH28 A8K648 E1P5U2 E1P5U1 Q9H6Q3 Q96QI4 Q5TH27 Q9H135 |
Accessions | EAW76116 EAW76117 EAW76118 EAW76119 Q9H6Q3 AF290985 AAL38197 AF290986 AAL38198 AF326353 AAL29204 AK025645 BAB15201 AK291513 BAF84202 BC042041 AAH42041 BF062179 BF510664 BQ052468 DA983348 XM_005260572 XP_005260629 NM_032214 NP_115590 NM_175077 NP_778252 |
Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}. |
Subcellular Location | Isoform 2: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes. |
Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
SLA2 CRISPR/Cas9 KO Plasmid (h) - sc-413569 from Santa Cruz Biotechnology
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SLA2 HDR Plasmid (h) - sc-413569-HDR from Santa Cruz Biotechnology
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SLA2 Double Nickase Plasmid (h) - sc-413569-NIC from Santa Cruz Biotechnology
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SLA2 Double Nickase Plasmid (h2) - sc-413569-NIC-2 from Santa Cruz Biotechnology
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SLA2 CRISPR Activation Plasmid (h) - sc-413569-ACT from Santa Cruz Biotechnology
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SLA2 CRISPR Activation Plasmid (h2) - sc-413569-ACT-2 from Santa Cruz Biotechnology
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SLA2 Lentiviral Activation Particles (h) - sc-413569-LAC from Santa Cruz Biotechnology
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SLA2 Lentiviral Activation Particles (h2) - sc-413569-LAC-2 from Santa Cruz Biotechnology
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SLA2 siRNA (h) - sc-76503 from Santa Cruz Biotechnology
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SLA2 shRNA Plasmid (h) - sc-76503-SH from Santa Cruz Biotechnology
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SLA2 shRNA (h) Lentiviral Particles - sc-76503-V from Santa Cruz Biotechnology
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Methionyl tRNA synthetase RNAi - H00004141-R01 from Novus Biologicals
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SLA2 RNAi - H00084174-R02 from Novus Biologicals
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SLA2 RNAi - H00084174-R01 from Novus Biologicals
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MISSION® esiRNA - EHU091641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19387 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19387 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09264 from Sigma-Aldrich
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SLA2 siRNA (Human) - CRJ3337 from Cohesion Biosciences
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SLA2 - MBS8202807 from MyBioSource
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shRNA set against Human SLA2 (NM_175077.2) - SHH408120 from Creative biogene
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SLA2 shRNA Plasmid (Human) - CHJ3337 from Cohesion Biosciences
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SLA2 miRNA 3'UTR clone - MiUTR3H-08577 from Creative biogene
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SLA2 miRNA 3'UTR clone - MiUTR3H-08578 from Creative biogene
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