| Gene Symbol |
SLA2
|
| Entrez Gene |
84174
|
| Alt Symbol |
C20orf156, MARS, SLAP-2, SLAP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Src-like-adaptor 2
|
| Other Description |
Src-like adapter protein-2|modulator of antigen receptor signaling|src-like-adapter 2
|
| Swissprots |
Q8WY18 Q5TH28 A8K648 E1P5U2 E1P5U1 Q9H6Q3 Q96QI4 Q5TH27 Q9H135
|
| Accessions |
EAW76116 EAW76117 EAW76118 EAW76119 Q9H6Q3 AF290985 AAL38197 AF290986 AAL38198 AF326353 AAL29204 AK025645 BAB15201 AK291513 BAF84202 BC042041 AAH42041 BF062179 BF510664 BQ052468 DA983348 XM_005260572 XP_005260629 NM_032214 NP_115590 NM_175077 NP_778252
|
| Function |
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}.
|
| Subcellular Location |
Isoform 2: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes.
|
| Tissue Specificity |
Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.
|