Gene Symbol | SLC40A1 |
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Entrez Gene | 30061 |
Alt Symbol | FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 40 (iron-regulated transporter), member 1 |
Other Description | iron regulated gene 1|putative ferroportin 1 variant IIIA|putative ferroportin 1 variant IIIB|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3|solute carrier family 40 member 1 |
Swissprots | Q9NRL0 Q7Z4F8 Q8IVB2 Q6FI62 Q9NP59 |
Accessions | AAX93082 CAE53170 CAE81347 CAE81348 CAE83578 CAI45360 CBM40849 EAX10901 EAX10902 Q9NP59 AF147322 AF171087 AAQ13603 AF215636 AAF80986 AF226614 AAF36697 AF231121 AAF44330 AK002038 BAA92049 AK223236 BAD96956 AK292146 BAF84835 AK314827 BAG37348 AL136944 CAB66878 AM393277 CAL38155 BC035893 AAH35893 BC037733 AAH37733 BX537503 CR533564 CAG38595 DA806565 DQ065759 AAY78556 DQ065760 AAY78557 DQ065761 AAY78558 DQ065762 AAY78559 DQ065763 AAY78560 DQ065764 AAY78561 DQ890880 ABM81806 DQ894034 ABM84960 XM_005246505 XP_005246562 NM_014585 NP_055400 |
Function | May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:23219802}; Multi-pass membrane protein {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:23219802}. Note=Localized to the basolateral membrane of polarized epithelial cells. |
Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen. {ECO:0000269|PubMed:10747949, ECO:0000269|PubMed:23219802}. |
Top Pathways | Mineral absorption |
Ferroportin-1 (G-16) - sc-49668 from Santa Cruz Biotechnology
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Anti-SLC40A1 antibody - ab85370 from Abcam
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Anti-SLC40A1 antibody - ab78066 from Abcam
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Anti-SLC40A1 antibody - ab58695 from Abcam
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Anti-SLC40A1 antibody [mAbcam93438] - ab93438 from Abcam
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Anti-SLC40A1 / Ferroportin-1 Antibody (C-Terminus) - LS-C16619 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (C-Terminus) - LS-C16620 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa250-300, Biotin) - LS-C143107 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa250-300, DY650) - LS-C143108 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa250-300, DY488) - LS-C143109 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa250-300, HRP) - LS-C143110 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa250-300, DY550) - LS-C143111 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa127-321, Biotin) - LS-C298410 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa127-321, FITC) - LS-C304446 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa395-444) - LS-C117170 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (aa127-321) - LS-C293864 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (Internal) IHC-plus⢠- LS-B10438 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (N-Terminus) - LS-C179226 from LifeSpan Bioscience
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Anti-SLC40A1 / Ferroportin-1 Antibody (N-Terminus) IHC-plus⢠- LS-B1836 from LifeSpan Bioscience
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Ferroportin/SLC40A1 Antibody - NBP1-21502 from Novus Biologicals
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Ferroportin/SLC40A1 Antibody - H00030061-B01 from Novus Biologicals
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Ferroportin/SLC40A1 Antibody [PE] - NBP1-21502PE from Novus Biologicals
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Ferroportin/SLC40A1 Antibody [DyLight 405] - NBP1-21502V from Novus Biologicals
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Ferroportin/SLC40A1 Antibody [FITC] - NBP1-21502F from Novus Biologicals
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Ferroportin/SLC40A1 Antibody [Alexa Fluor (R) 700] - NBP1-21502AF700 from Novus Biologicals
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