MAP2K7

Gene Symbol	MAP2K7
Entrez Gene	5609
Alt Symbol	JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase 7
Other Description	JNK-activating kinase 2|MAP kinase kinase 7|MAPK/ERK kinase 7|SAPK kinase 4|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7|stress-activated protein kinase kinase 4
Swissprots	O14816 O14733 Q8IY10 D6W659 O60452 B2R9S5 Q1PG43 O14648 O60453
Accessions	EAW68962 EAW68963 EAW68964 EAW68965 EAW68966 EAW68967 EAW68968 O14733 AF003199 AAB63374 AF006689 AAB97813 AF013588 AAC16272 AF013589 AAC16273 AF014401 AAB88048 AF022805 AAC26142 AK098807 AK300988 BAG62607 AK313899 BAG36622 BC005365 BC038295 AAH38295 BF445461 DQ445915 ABE03013 DQ891274 ABM82200 DQ894462 ABM85388 HY063492 HY099294 XM_006722800 XP_006722863 NM_001297555 NP_001284484 NM_001297556 NP_001284485 NM_145185 NP_660186
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}.
Tissue Specificity	Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. {ECO:0000269|PubMed:16442502, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930}.
Top Pathways	Neurotrophin signaling pathway, TNF signaling pathway, Epstein-Barr virus infection, Influenza A, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-MKK7 (Ser271/Thr275) Antibody - 4171 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

MKK7 Antibody - 4172 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

MEK-7 (E-7) - sc-25288 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MEK-7 (T-19) - sc-7104 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEK-7 (C-19) - sc-7103 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEK-7 (H-160) - sc-13071 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-MEK7 (phospho S271 + T275) antibody - ab4762 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-MEK7 (phospho T275) antibody - ab192592 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MEK7 antibody - ab154732 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MEK7 antibody - ab18565 from Abcam Prices $372.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEK7 antibody - ab171763 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MEK7 antibody - ab79364 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEK7 antibody - ab57731 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MEK7 antibody - ab57732 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MEK7 antibody [4E5] - ab119934 from Abcam Host Mouse Clonality Monoclonal Clone 4E5

Anti-MEK7 antibody [EP1455Y] - ab52618 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1455Y

Anti-MAP2K7 / MEK7 Antibody - LS-C16401 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MAP2K7 / MEK7 Antibody (aa4-29) - LS-C83975 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP2K7 / MEK7 Antibody (phospho-Ser271/Thr275) - LS-C182038 from LifeSpan Bioscience Prices $515.00 Sizes 10 blot Host Rabbit Clonality Polyclonal

Anti-MAP2K7 / MEK7 Antibody (aa236-285) - LS-C118313 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP2K7 / MEK7 Antibody (aa287-336) - LS-C111215 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MAP2K7 / MEK7 Antibody (C-Terminus, clone EP1455Y) - LS-C49905 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1455Y

Anti-MAP2K7 / MEK7 Antibody (aa205-233, APC) - LS-C262540 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP2K7 / MEK7 Antibody (phospho-Thr275/Ser277) - LS-C152799 from LifeSpan Bioscience Prices $385.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MAP2K7 / MEK7 Antibody (aa205-233, AP) - LS-C262541 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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