| Gene Symbol |
MAP2K7
|
| Entrez Gene |
5609
|
| Alt Symbol |
JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase 7
|
| Other Description |
JNK-activating kinase 2|MAP kinase kinase 7|MAPK/ERK kinase 7|SAPK kinase 4|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7|stress-activated protein kinase kinase 4
|
| Swissprots |
O14816 O14733 Q8IY10 D6W659 O60452 B2R9S5 Q1PG43 O14648 O60453
|
| Accessions |
EAW68962 EAW68963 EAW68964 EAW68965 EAW68966 EAW68967 EAW68968 O14733 AF003199 AAB63374 AF006689 AAB97813 AF013588 AAC16272 AF013589 AAC16273 AF014401 AAB88048 AF022805 AAC26142 AK098807 AK300988 BAG62607 AK313899 BAG36622 BC005365 BC038295 AAH38295 BF445461 DQ445915 ABE03013 DQ891274 ABM82200 DQ894462 ABM85388 HY063492 HY099294 XM_006722800 XP_006722863 NM_001297555 NP_001284484 NM_001297556 NP_001284485 NM_145185 NP_660186
|
| Function |
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. {ECO:0000269|PubMed:16442502, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930}.
|
| Top Pathways |
Neurotrophin signaling pathway, TNF signaling pathway, Epstein-Barr virus infection, Influenza A, Osteoclast differentiation
|