MAP2K7

Gene Symbol	MAP2K7
Entrez Gene	5609
Alt Symbol	JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase 7
Other Description	JNK-activating kinase 2|MAP kinase kinase 7|MAPK/ERK kinase 7|SAPK kinase 4|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7|stress-activated protein kinase kinase 4
Swissprots	O14816 O14733 Q8IY10 D6W659 O60452 B2R9S5 Q1PG43 O14648 O60453
Accessions	EAW68962 EAW68963 EAW68964 EAW68965 EAW68966 EAW68967 EAW68968 O14733 AF003199 AAB63374 AF006689 AAB97813 AF013588 AAC16272 AF013589 AAC16273 AF014401 AAB88048 AF022805 AAC26142 AK098807 AK300988 BAG62607 AK313899 BAG36622 BC005365 BC038295 AAH38295 BF445461 DQ445915 ABE03013 DQ891274 ABM82200 DQ894462 ABM85388 HY063492 HY099294 XM_006722800 XP_006722863 NM_001297555 NP_001284484 NM_001297556 NP_001284485 NM_145185 NP_660186
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}.
Tissue Specificity	Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. {ECO:0000269|PubMed:16442502, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930}.
Top Pathways	Neurotrophin signaling pathway, TNF signaling pathway, Epstein-Barr virus infection, Influenza A, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® MKK7 siRNA II - 6323 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® MKK7 siRNA I - 6322 from Cell Signaling Technology Category siRNA

MEK-7 CRISPR/Cas9 KO Plasmid (h) - sc-402363 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 HDR Plasmid (h) - sc-402363-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 Double Nickase Plasmid (h) - sc-402363-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 Double Nickase Plasmid (h2) - sc-402363-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 CRISPR Activation Plasmid (h) - sc-402363-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 CRISPR Activation Plasmid (h2) - sc-402363-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 Lentiviral Activation Particles (h) - sc-402363-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 Lentiviral Activation Particles (h2) - sc-402363-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-7 siRNA (h) - sc-35915 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MEK-7 shRNA Plasmid (h) - sc-35915-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MEK-7 shRNA (h) Lentiviral Particles - sc-35915-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MKK7/MEK7 RNAi - H00005609-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU136181 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1115 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1114 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1116 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN12986 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12986 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MAP2K7 siRNA (Human) - CRH3779 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MAP2K7 (NM_145185.2) - SHH337599 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MAP2K7(NM_145185.2) - SHH173765 from Creative biogene Category siRNA Species Reactivities Human

MAP2K7 shRNA Plasmid (Human) - CHH3779 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MAP2K7 miRNA 3'UTR clone - MiUTR1H-06057 from Creative biogene Species Reactivities Human

Search more