MAP2K7

Gene Symbol	MAP2K7
Entrez Gene	5609
Alt Symbol	JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase 7
Other Description	JNK-activating kinase 2|MAP kinase kinase 7|MAPK/ERK kinase 7|SAPK kinase 4|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7|stress-activated protein kinase kinase 4
Swissprots	O14816 O14733 Q8IY10 D6W659 O60452 B2R9S5 Q1PG43 O14648 O60453
Accessions	EAW68962 EAW68963 EAW68964 EAW68965 EAW68966 EAW68967 EAW68968 O14733 AF003199 AAB63374 AF006689 AAB97813 AF013588 AAC16272 AF013589 AAC16273 AF014401 AAB88048 AF022805 AAC26142 AK098807 AK300988 BAG62607 AK313899 BAG36622 BC005365 BC038295 AAH38295 BF445461 DQ445915 ABE03013 DQ891274 ABM82200 DQ894462 ABM85388 HY063492 HY099294 XM_006722800 XP_006722863 NM_001297555 NP_001284484 NM_001297556 NP_001284485 NM_145185 NP_660186
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}.
Tissue Specificity	Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. {ECO:0000269|PubMed:16442502, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930}.
Top Pathways	Neurotrophin signaling pathway, TNF signaling pathway, Epstein-Barr virus infection, Influenza A, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MEK7 full length protein - ab159222 from Abcam Category Protein Source Wheat germ Species Human

Human MEK7 protein fragment - ab159223 from Abcam Category Protein Source Wheat germ Species Human

MAP2K7 / MEK7 Antibody Blocking Peptide - LS-E3023 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP2K7 / MEK7 Antibody Blocking Peptide - LS-E17735 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MKK7/MEK7 Protein - H00005609-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MKK7/MEK7 Protein - H00005609-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MKK7/MEK7 Peptide - P2902 from Novus Biologicals Category Peptide Species Human

MKK7-S271T275-Antibody-Center-Blocking-peptide - BP7918d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MKK7-Antibody-C-term-Blocking-Peptide - BP7918a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAP2K7 Blocking Peptide - 33R-2695 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human MAP2K7 Protein - abx068038 from Abbexa Category Protein Source E.coli Species Human

MAP2K7 - H00005609-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MAP2K7 - H00005609-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAP2K7 - H00005609-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAP2K7 - P5587 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

MAP2K7 - P5678 from Acris Antibodies Category Protein Prices $840.00 Sizes 50 µg Species Human

MAP2K7 - P5685 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 50 µg Species Human

Mitogen Activated Protein Kinase Kinase 7 (MAP2K7), Human - 20-8814 from ARP American Research Products Category Protein Prices $459.00 Sizes 50 µg Source E.coli Species Human

Recombinant Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) - RPD560Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) - RPD560Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

MKK7β1 Protein, active, 250 µg - 14-543M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-543) and in bulk (cat# 14-543-K) Source Human MKK7β expressed in E. coli.

MKK7β1 Protein, unactive, 50 µg - 14-542 from EMD Millipore Category Protein Prices $401.00 Sizes 50 µg Source expressed in E. coli

MEK-7 (I264) Peptide - BS3747P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) - RPD560Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Dual specificity mitogen-activated protein kinase kinase 7(MAP - CSB-YP013416HU CSB-EP013416HU CSB-BP013416HU CSB-MP013416HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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