MAP2K7
| Gene Symbol | MAP2K7 |
|---|---|
| Entrez Gene | 5609 |
| Alt Symbol | JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase kinase 7 |
| Other Description | JNK-activating kinase 2|MAP kinase kinase 7|MAPK/ERK kinase 7|SAPK kinase 4|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7|stress-activated protein kinase kinase 4 |
| Swissprots | O14816 O14733 Q8IY10 D6W659 O60452 B2R9S5 Q1PG43 O14648 O60453 |
| Accessions | EAW68962 EAW68963 EAW68964 EAW68965 EAW68966 EAW68967 EAW68968 O14733 AF003199 AAB63374 AF006689 AAB97813 AF013588 AAC16272 AF013589 AAC16273 AF014401 AAB88048 AF022805 AAC26142 AK098807 AK300988 BAG62607 AK313899 BAG36622 BC005365 BC038295 AAH38295 BF445461 DQ445915 ABE03013 DQ891274 ABM82200 DQ894462 ABM85388 HY063492 HY099294 XM_006722800 XP_006722863 NM_001297555 NP_001284484 NM_001297556 NP_001284485 NM_145185 NP_660186 |
| Function | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr |
| Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. {ECO:0000269|PubMed:16442502, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930}. |
| Top Pathways | Neurotrophin signaling pathway, TNF signaling pathway, Epstein-Barr virus infection, Influenza A, Osteoclast differentiation |
Mouse/Human/Rat Phospho-MAP2K7 / MEK7 (Ser271) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1687 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-MAP2K7 / MEK7 (Thr275) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1688 from LifeSpan Bioscience
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Mouse/Human/Rat MAP2K7 / MEK7 ELISA Kit (Cell-Based ELISA) - LS-F2125 from LifeSpan Bioscience
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MAP2K7 Colorimetric Cell-Based ELISA Kit - CB5424 from Assay Biotechnology
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MAP2K7 (Phospho-Ser271) Colorimetric Cell-Based ELISA Kit - CBP1754 from Assay Biotechnology
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MAP2K7 (Phospho-Thr275) Colorimetric Cell-Based ELISA Kit - CBP1755 from Assay Biotechnology
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MEK(Methionine-Enkephalin) ELISA Kit - E-EL-0020 from Elabscience
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MEK, ELISA Kit - MBS2516185 from MyBioSource
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mitogen-activated protein kinase kinase 7, ELISA Kit - MBS9334956 from MyBioSource
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Rat MAP2K7 / MEK7 ELISA Kit (Custom ELISA) - LS-F17833 from LifeSpan Bioscience
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Human MAP2K7 / MEK7 ELISA Kit (Custom ELISA) - LS-F17835 from LifeSpan Bioscience
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Mouse MAP2K7 / MEK7 ELISA Kit (Custom ELISA) - LS-F17834 from LifeSpan Bioscience
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MEK (Methionine-Enkephalin) ELISA Kit - E-EL-0020 from Iwai North America Inc.
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MAP2K7 ELISA Kit - DEIA-XYA1157 from Creative Diagnostics
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MAP2K7 (Phospho-Ser271) ELISA Kit - DEIA-XYA1158 from Creative Diagnostics
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MAP2K7 (Phospho-Thr275) ELISA Kit - DEIA-XYA1159 from Creative Diagnostics
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Custom Human MKK7/MAP2K7 ELISA - ELH-MKK7-1 from RayBiotech
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Custom Human MAP2K7 ELISA Kit - orb384667 from Biorbyt
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Human MAP2K7 ELISA Kit - E012431 from Biobool
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Dual specificity mitogen-activated protein kinase kinase 7, ELISA Kit - MBS289719 from MyBioSource
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Dual specificity mitogen-activated protein kinase kinase 7, ELISA Kit - MBS761565 from MyBioSource
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Mouse MAP2K7 / MEK7 ELISA Kit (Sandwich ELISA) - LS-F34951 from LifeSpan Bioscience
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MAP2K7 Colorimetric Cell-Based ELISA Kit - EKA50360 from Biomatik
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