| Gene Symbol |
FARS2
|
| Entrez Gene |
10667
|
| Alt Symbol |
COXPD14, FARS1, HSPC320, PheRS, dJ520B18.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phenylalanyl-tRNA synthetase 2, mitochondrial
|
| Other Description |
dJ236A3.1 (phenylalanine-tRNA synthetase)|dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))|phenylalanine tRNA ligase 2, mitochondrial|phenylalanine translase|phenylalanine--tRNA ligase, mitochondrial|phenylalanine-tRNA synthetase 1 (mitochondrial)
|
| Swissprots |
B2R664 Q5TCS3 O95363 Q53F66 Q9P062 Q9NPY7 Q6FG29
|
| Accessions |
EAW55179 O95363 AF097441 AAC83802 AF161438 AAF28998 AI338405 AK001146 AK223423 BAD97143 AK312454 BAG35361 BC020239 AAH20239 BC021112 AAH21112 BE792999 BG212473 BI761156 CN292346 CR542279 CAG47075 CR591198 XM_005248811 XP_005248868 XM_005248812 XP_005248869 XM_006714966 XP_006715029 XM_011514247 XP_011512549 XM_011514248 XP_011512550 XM_011514249 XP_011512551 XM_011514250 XP_011512552 XM_011514251 XP_011512553 XR_926026 XR_926027 XR_926028 NM_006567 NP_006558
|
| Function |
Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. {ECO:0000269|PubMed:19549855, ECO:0000269|PubMed:22833457}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000305}.
|
| Top Pathways |
Aminoacyl-tRNA biosynthesis
|