Gene Symbol | FARS2 |
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Entrez Gene | 10667 |
Alt Symbol | COXPD14, FARS1, HSPC320, PheRS, dJ520B18.2 |
Species | Human |
Gene Type | protein-coding |
Description | phenylalanyl-tRNA synthetase 2, mitochondrial |
Other Description | dJ236A3.1 (phenylalanine-tRNA synthetase)|dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))|phenylalanine tRNA ligase 2, mitochondrial|phenylalanine translase|phenylalanine--tRNA ligase, mitochondrial|phenylalanine-tRNA synthetase 1 (mitochondrial) |
Swissprots | B2R664 Q5TCS3 O95363 Q53F66 Q9P062 Q9NPY7 Q6FG29 |
Accessions | EAW55179 O95363 AF097441 AAC83802 AF161438 AAF28998 AI338405 AK001146 AK223423 BAD97143 AK312454 BAG35361 BC020239 AAH20239 BC021112 AAH21112 BE792999 BG212473 BI761156 CN292346 CR542279 CAG47075 CR591198 XM_005248811 XP_005248868 XM_005248812 XP_005248869 XM_006714966 XP_006715029 XM_011514247 XP_011512549 XM_011514248 XP_011512550 XM_011514249 XP_011512551 XM_011514250 XP_011512552 XM_011514251 XP_011512553 XR_926026 XR_926027 XR_926028 NM_006567 NP_006558 |
Function | Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. {ECO:0000269|PubMed:19549855, ECO:0000269|PubMed:22833457}. |
Subcellular Location | Mitochondrion matrix {ECO:0000305}. |
Top Pathways | Aminoacyl-tRNA biosynthesis |
Human FARS2 protein fragment - ab105613 from Abcam
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FARS2 Antibody Blocking Peptide - LS-E14894 from LifeSpan Bioscience
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FARS2 Partial Recombinant Protein - H00010667-Q01 from Novus Biologicals
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FARS2 Recombinant Protein - H00010667-P01 from Novus Biologicals
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Recombinant Human FARS2 Protein - NBP1-51083 from Novus Biologicals
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Human FARS2 protein - orb168327 from Biorbyt
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FARS2 Blocking Peptide - 33R-9501 from Fitzgerald
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FARS2 protein (His tag) - 80R-1772 from Fitzgerald
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FARS2 (37-451, His-tag) - AR09955PU-L from Acris Antibodies
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FARS2 (37-451, His-tag) - AR09955PU-N from Acris Antibodies
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FARS2 - H00010667-P01 from Acris Antibodies
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FARS2 - H00010667-Q01-10 from Acris Antibodies
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FARS2 - H00010667-Q01-25 from Acris Antibodies
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Phenylalanyl-tRNA Synthetase 2, Human Recombinant - 228-12263-1 from RayBiotech
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FARS2, 37-451aa, Human, His tag, E.coli - 01-P1015 from ARP American Research Products
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FARS2 fusion protein - Ag9750 from Proteintech Group
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FARS2 fusion protein - Ag9913 from Proteintech Group
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FARS2 Human Protein - GWB-BSP175 from Genway Biotech
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FARS2, 37-451aa, Recombinant Protein - GWB-P1023I from Genway Biotech
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Recombinant Human Phenylalanyl-tRNA Synthetase 2, His-tagged - FARS2-976H from Creative Biomart
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Recombinant Human FARS2, His-tagged - FARS2-28164TH from Creative Biomart
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Recombinant Human FARS2, GST-tagged - FARS2-12748H from Creative Biomart
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FARS2 37-451aa - CMB-848 from Reagent Proteins
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Recombinant Human Phenylalanine--tRNA ligase, mitochondrial(FARS2) - CSB-YP008429HU CSB-EP008429HU CSB-BP008429HU CSB-MP008429HU from Cusabio
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FARS2, 37-451aa, Human, His tag, E.coli - ATGP1015 from ATGen
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