WARS

Gene Symbol	WARS
Entrez Gene	7453
Alt Symbol	GAMMA-2, IFI53, IFP53
Species	Human
Gene Type	protein-coding
Description	tryptophanyl-tRNA synthetase
Other Description	hWRS\|interferon-induced protein 53\|trpRS\|tryptophan tRNA ligase 1, cytoplasmic\|tryptophan--tRNA ligase, cytoplasmic
Swissprots	Q9UDL3 A6NID3 P23381 Q502Y0 A6NGN1 Q53XB6 P78535 Q9UDI5
Accessions	AAB39380 AAB39381 CAB94198 CAB94199 EAW81700 EAW81701 EAW81702 EAW81703 P23381 AK025487 AK056100 BAG51626 AK124668 AK130698 AK291141 BAF83830 AK300255 BAG62020 AV710027 BC017489 AAH17489 BC095453 AAH95453 BG717903 BM561448 BM834473 BX248006 CAD62335 M61715 AAA61298 M77804 AAA67324 X59892 CAA42545 X62570 CAA44450 XM_005268044 XP_005268101 XM_006720249 XP_006720312 XM_011537133 XP_011535435 XM_011537134 XP_011535436 XM_011537135 XP_011535437 XM_011537136 XP_011535438 XM_011537137 XP_011535439 NM_004184 NP_004175 NM_173701 NP_776049 NM_213645 NP_998810 NM_213646 NP_998811
Function	Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. {ECO:0000269\|PubMed:11773625, ECO:0000269\|PubMed:11773626, ECO:0000269\|PubMed:1373391, ECO:0000269\|PubMed:14630953}.
Subcellular Location	Cytoplasm.
Top Pathways	Aminoacyl-tRNA biosynthesis

TrpRS (C-7) - sc-374401 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TrpRS (C-7): sc-374401. Western blot analysis of TrpRS expression in JAR (A) and HeLa (B) whole cell lysates.

TrpRS (H-300) - sc-48810 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

TrpRS (H-300): sc-48810. Western blot analysis of TrpRS expression in non-transfected 293T: sc-117752 (A) and mouse TrpRS transfected 293T: sc-124308 (B) and HeLa (C) whole cell lysates.

TrpRS (E-17) - sc-22983 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TrpRS (N-17) - sc-22982 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TrpRS (N-17): sc-22982. Western blot analysis of TrpRS expression in human PBL (A) and JAR (B) whole cell lysates and Jurkat (C) nuclear extract.

TrpRS (16-R) - sc-100984 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

TrpRS (16-R): sc-100984. Western blot analysis of TrpRS expression in HeLa whole cell lysate.

Anti-Tryptophanyl tRNA synthetase antibody - ab31536 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Tryptophanyl tRNA synthetase antibody (ab31536) at 1/5000 dilution + whole cell lysate prepared from HEK293 cells at 50 µg/mlSecondaryGoat anti-rabbit IgG (H+L) at 1/10000 dilution

Anti-Tryptophanyl tRNA synthetase antibody - ab155203 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Tryptophanyl tRNA synthetase antibody (ab155203) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-Tryptophanyl tRNA synthetase antibody - ab58054 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-Tryptophanyl tRNA synthetase antibody - ab86336 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Tryptophanyl tRNA synthetase antibody (ab86336) at 1 µg/ml + Human fetal brain lysate at 10 µgSecondaryanti-Rabbit IgG HRP at 1/50000 dilution

Anti-Tryptophanyl tRNA synthetase antibody [EPR3423] - ab109213 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3423

All lanes : Anti-Tryptophanyl tRNA synthetase antibody [EPR3423] (ab109213) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : JAR cell lysateLane 3 : 293T cell lysateLane 4 : L6 cell lysateLysates/proteins at 10 µg per lane.

Anti-Tryptophanyl tRNA synthetase antibody [EPR3424] - ab92733 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3424

All lanes : Anti-Tryptophanyl tRNA synthetase antibody [EPR3424] (ab92733) at 1/10000 dilutionLane 1 : JAR cell lysateLane 2 : 293T cell lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-WARS Antibody (aa429-458, AP) - LS-C273415 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa429-458, APC) - LS-C273416 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa429-458, Biotin) - LS-C273417 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa429-458, FITC) - LS-C273418 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa429-458, Azide-free, HRP) - LS-C273419 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa429-458, PE) - LS-C273420 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa228-258) - LS-C326310 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa50-150, Azide-free) - LS-C329096 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-WARS Antibody (aa429-458) - LS-C157360 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

WARS Antibody western blot of Jurkat cell line lysates (35 ug/lane). The WARS antibody detected the WARS protein (arrow).

Anti-WARS Antibody - LS-C341873 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa421-471) - LS-C290917 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human and Mouse WARS by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-WARS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-WARS Antibody (aa1-50) - LS-C290915 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa247-458) - LS-C296833 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-WARS Antibody (aa140-347) - LS-C296834 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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