WARS

Gene Symbol WARS
Entrez Gene 7453
Alt Symbol GAMMA-2, IFI53, IFP53
Species Human
Gene Type protein-coding
Description tryptophanyl-tRNA synthetase
Other Description hWRS|interferon-induced protein 53|trpRS|tryptophan tRNA ligase 1, cytoplasmic|tryptophan--tRNA ligase, cytoplasmic
Swissprots Q9UDL3 A6NID3 P23381 Q502Y0 A6NGN1 Q53XB6 P78535 Q9UDI5
Accessions AAB39380 AAB39381 CAB94198 CAB94199 EAW81700 EAW81701 EAW81702 EAW81703 P23381 AK025487 AK056100 BAG51626 AK124668 AK130698 AK291141 BAF83830 AK300255 BAG62020 AV710027 BC017489 AAH17489 BC095453 AAH95453 BG717903 BM561448 BM834473 BX248006 CAD62335 M61715 AAA61298 M77804 AAA67324 X59892 CAA42545 X62570 CAA44450 XM_005268044 XP_005268101 XM_006720249 XP_006720312 XM_011537133 XP_011535435 XM_011537134 XP_011535436 XM_011537135 XP_011535437 XM_011537136 XP_011535438 XM_011537137 XP_011535439 NM_004184 NP_004175 NM_173701 NP_776049 NM_213645 NP_998810 NM_213646 NP_998811
Function Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:14630953}.
Subcellular Location Cytoplasm.
Top Pathways Aminoacyl-tRNA biosynthesis

TrpRS CRISPR/Cas9 KO Plasmid (h) - sc-405512 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS HDR Plasmid (h) - sc-405512-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS Double Nickase Plasmid (h) - sc-405512-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS Double Nickase Plasmid (h2) - sc-405512-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS CRISPR Activation Plasmid (h) - sc-405512-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS CRISPR Activation Plasmid (h2) - sc-405512-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS Lentiviral Activation Particles (h) - sc-405512-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS Lentiviral Activation Particles (h2) - sc-405512-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TrpRS siRNA (h) - sc-37673 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TrpRS shRNA Plasmid (h) - sc-37673-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TrpRS shRNA (h) Lentiviral Particles - sc-37673-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tryptophanyl tRNA synthetase RNAi - H00007453-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Tryptophanyl tRNA synthetase RNAi - H00007453-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

Tryptophanyl tRNA synthetase RNAi - H00007453-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU061671 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22773 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22773 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12470 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12470

WARS siRNA (Human) - CRH5098 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Tryptophanyl tRNA synthetase RNAi - H00007453-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

WARS - MBS8229144 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human WARS (NM_004184.3) - SHH445564 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WARS(NM_004184.3) - SHL129234 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WARS(NM_213645.1) - SHL129486 from Creative biogene

Category siRNA
Species Reactivities Human

WARS shRNA Plasmid (Human) - CHH5098 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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