Gene Symbol | ADCK3 |
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Entrez Gene | 56997 |
Alt Symbol | ARCA2, CABC1, COQ10D4, COQ8, SCAR9 |
Species | Human |
Gene Type | protein-coding |
Description | aarF domain containing kinase 3 |
Other Description | aarF domain-containing protein kinase 3|atypical kinase ADCK3, mitochondrial|chaperone activity of bc1 complex-like, mitochondrial|chaperone, ABC1 activity of bc1 complex homolog|coenzyme Q8 homolog |
Swissprots | Q63HK0 Q9HBQ1 Q5T7A5 Q9NQ67 Q8NCJ6 Q8NI60 |
Accessions | EAW69801 EAW69802 EAW69803 EAW69804 EAW69805 Q8NI60 AB073905 BAB91363 AF218003 AAG17245 AI888739 AJ278126 CAC00482 AK074693 BAC11143 AK090494 BAG52171 AK092784 AK126200 AK293571 BAG57042 AK297735 BAG60085 AK300537 BAG62245 AK301012 BAG62629 AL137511 BC005171 AAH05171 BC129930 AAI29931 BX648860 CAH56132 DA925261 XM_005273201 XP_005273258 XM_011544238 XP_011542540 XM_011544239 XP_011542541 XM_011544240 XP_011542542 XM_011544241 XP_011542543 NM_020247 NP_064632 |
Function | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144). Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway (PubMed:25498144). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144). {ECO:0000269|PubMed:25498144, ECO:0000305|PubMed:21296186, ECO:0000305|PubMed:25540914}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:11888884, ECO:0000269|PubMed:25498144}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:25216398}. |
Tissue Specificity | Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. {ECO:0000269|PubMed:24270420}. |
CABC1 (G-14) - sc-103417 from Santa Cruz Biotechnology
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CABC1 (H-41) - sc-366173 from Santa Cruz Biotechnology
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CABC1 (687) - sc-100663 from Santa Cruz Biotechnology
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Anti-ADCK3 antibody - ab64816 from Abcam
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Anti-ADCK3 antibody - ab57525 from Abcam
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Anti-ADCK3 antibody - ab57541 from Abcam
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Anti-ADCK3 / CABC1 Antibody (clone 216CT7.5.1, APC) - LS-C221260 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (clone 216CT7.5.1, AP) - LS-C221256 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (clone 216CT7.5.1, Biotin) - LS-C221261 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa146-195) - LS-C81228 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (clone 216CT7.5.1, Azide-free, HRP) - LS-C221263 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (clone 216CT7.5.1, PE) - LS-C221264 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa472-521) - LS-C186686 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (clone 216CT7.5.1, FITC) - LS-C221262 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa395-423, APC) - LS-C221596 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa301-350) - LS-C119157 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody - LS-C168252 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa396-423) - LS-C164308 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa395-423, Biotin) - LS-C221597 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa395-423, AP) - LS-C221595 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa516-545) - LS-C98303 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa395-423, PE) - LS-C221600 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa395-423, Azide-free, HRP) - LS-C221599 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody - LS-C309675 from LifeSpan Bioscience
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Anti-ADCK3 / CABC1 Antibody (aa395-423, FITC) - LS-C221598 from LifeSpan Bioscience
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