| Gene Symbol | ADCK3 |
|---|---|
| Entrez Gene | 56997 |
| Alt Symbol | ARCA2, CABC1, COQ10D4, COQ8, SCAR9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aarF domain containing kinase 3 |
| Other Description | aarF domain-containing protein kinase 3|atypical kinase ADCK3, mitochondrial|chaperone activity of bc1 complex-like, mitochondrial|chaperone, ABC1 activity of bc1 complex homolog|coenzyme Q8 homolog |
| Swissprots | Q63HK0 Q9HBQ1 Q5T7A5 Q9NQ67 Q8NCJ6 Q8NI60 |
| Accessions | EAW69801 EAW69802 EAW69803 EAW69804 EAW69805 Q8NI60 AB073905 BAB91363 AF218003 AAG17245 AI888739 AJ278126 CAC00482 AK074693 BAC11143 AK090494 BAG52171 AK092784 AK126200 AK293571 BAG57042 AK297735 BAG60085 AK300537 BAG62245 AK301012 BAG62629 AL137511 BC005171 AAH05171 BC129930 AAI29931 BX648860 CAH56132 DA925261 XM_005273201 XP_005273258 XM_011544238 XP_011542540 XM_011544239 XP_011542541 XM_011544240 XP_011542542 XM_011544241 XP_011542543 NM_020247 NP_064632 |
| Function | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144). Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway (PubMed:25498144). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144). {ECO:0000269|PubMed:25498144, ECO:0000305|PubMed:21296186, ECO:0000305|PubMed:25540914}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:11888884, ECO:0000269|PubMed:25498144}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:25216398}. |
| Tissue Specificity | Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. {ECO:0000269|PubMed:24270420}. |
Chaperone activity of bc1 complex-like, mitochondrial (CABC1), Human, ELISA Kit - E01C1294 from ARP American Research Products
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Chaperone activity of bc1 complex like, mitochondrial (CABC1), ELISA Kit - MBS7215763 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7215365 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7247394 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7204439 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7202399 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7250278 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7221869 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7249281 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7218366 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7220722 from MyBioSource
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Chaperone activity of bc1 complex-like, mitochondrial (CABC1), ELISA Kit - MBS7252986 from MyBioSource
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