| Gene Symbol |
ADAM12
|
| Entrez Gene |
8038
|
| Alt Symbol |
ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase domain 12
|
| Other Description |
disintegrin and metalloproteinase domain-containing protein 12|meltrin-alpha|metalloprotease-disintegrin 12 transmembrane
|
| Swissprots |
Q6UWB0 Q5JRP0 O60470 Q5JRP1 Q6P9E3 O43184
|
| Accessions |
CBH19188 EAW49205 EAW49206 EAW49207 EAW49208 EAW49209 O43184 AF023476 AAC08702 AF023477 AAC08703 AK055628 AK127856 AK291629 BAF84318 AY358878 AAQ89237 BC060804 AAH60804 BX098286 CB960379 DA027173 DA863951 DR004947 HG975387 KF444157 AGX93290 T91975 NM_001288973 NP_001275902 NM_001288974 NP_001275903 NM_001288975 NP_001275904 NM_003474 NP_003465 NM_021641 NP_067673
|
| Function |
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Isoform 3: Secreted {ECO:0000305}.
|
| Tissue Specificity |
Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
|