Gene Symbol | AMER2 |
---|---|
Entrez Gene | 219287 |
Alt Symbol | FAM123A |
Species | Human |
Gene Type | protein-coding |
Description | APC membrane recruitment protein 2 |
Other Description | family with sequence similarity 123A|protein FAM123A |
Swissprots | Q5RL80 Q5VX56 Q8N7J2 Q8N593 Q96NN5 |
Accessions | EAX08363 EAX08364 Q8N7J2 AK055049 BAB70845 AK055278 AK094378 AK098054 AK098343 BAC05288 AK098796 BAC05414 AL832586 AL832627 BC032653 AAH32653 BC041392 AAH41392 BC045677 BM680074 DA210701 XM_005266279 XP_005266336 XM_005266280 XP_005266337 XM_006719770 XP_006719833 NM_152704 NP_689917 NM_199138 NP_954589 |
Function | Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269|PubMed:22128170}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:22128170}; Peripheral membrane protein {ECO:0000269|PubMed:22128170}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. |
FAM123A (G-1) - sc-374654 from Santa Cruz Biotechnology
|
||||||||
FAM123A (K-15) - sc-84112 from Santa Cruz Biotechnology
|
||||||||
FAM123A (N-17) - sc-84113 from Santa Cruz Biotechnology
|
||||||||
FAM123A (H-39) - sc-292972 from Santa Cruz Biotechnology
|
||||||||
Anti-FAM123A antibody - ab122556 from Abcam
|
||||||||
Anti-FAM123A antibody - ab125412 from Abcam
|
||||||||
FAM123A Antibody - NBP1-93907 from Novus Biologicals
|
||||||||
Anti-AMER2 antibody produced in rabbit - HPA039458 from Sigma-Aldrich
|
||||||||
Anti-AMER2 antibody produced in rabbit - HPA039728 from Sigma-Aldrich
|
||||||||
FAM123A antibody - orb183526 from Biorbyt
|
||||||||
Anti-AMER2 (aa 431-515) polyclonal antibody - DPABH-20860 from Creative Diagnostics
|
||||||||
Rabbit anti-Human FAM123A polyclonal antibody - DPABH-20885 from Creative Diagnostics
|
||||||||
FAM123A antibody (FITC) - orb187839 from Biorbyt
|
||||||||
Anti-FAM123A polyclonal antibody - CABT-BL1424 from Creative Diagnostics
|
||||||||
Anti-FAM123A polyclonal antibody - CABT-BL1425 from Creative Diagnostics
|
||||||||
Anti-Fam123a Antibody A11360 - A11360 from Boster Bio
|
||||||||
FAM123A Antibody - middle region (ARP79718_P050) - ARP79718_P050 from Aviva Systems Biology
|