| Gene Symbol | AMER2 |
|---|---|
| Entrez Gene | 219287 |
| Alt Symbol | FAM123A |
| Species | Human |
| Gene Type | protein-coding |
| Description | APC membrane recruitment protein 2 |
| Other Description | family with sequence similarity 123A|protein FAM123A |
| Swissprots | Q5RL80 Q5VX56 Q8N7J2 Q8N593 Q96NN5 |
| Accessions | EAX08363 EAX08364 Q8N7J2 AK055049 BAB70845 AK055278 AK094378 AK098054 AK098343 BAC05288 AK098796 BAC05414 AL832586 AL832627 BC032653 AAH32653 BC041392 AAH41392 BC045677 BM680074 DA210701 XM_005266279 XP_005266336 XM_005266280 XP_005266337 XM_006719770 XP_006719833 NM_152704 NP_689917 NM_199138 NP_954589 |
| Function | Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269|PubMed:22128170}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:22128170}; Peripheral membrane protein {ECO:0000269|PubMed:22128170}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. |
Human FAM123A cDNA clone(NM_152704.2) - CDFG009691 from Creative Biomart
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Human FAM123A cDNA clone(NM_199138.1) - CDFG013049 from Creative Biomart
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Human FAM123A ORF clone(NM_152704.2) - CDCG001623 from Creative Biomart
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Human FAM123A ORF Clone(NM_152704.2) - CDCL162915 from Creative Biomart
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Human FAM123A ORF Clone(NM_152704.2) - CDCR319950 from Creative Biomart
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Human FAM123A ORF Clone(NM_152704.2) - CDCR319951 from Creative Biomart
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Human FAM123A ORF Clone(NM_199138.1) - CDCR326266 from Creative Biomart
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Human FAM123A ORF Clone(NM_199138.1) - CDCR326267 from Creative Biomart
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Human FAM123A ORF clone (NM_152704.2) - CDCR062516 from Creative biogene
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Human FAM123A ORF clone (NM_199138.1) - CDCR062518 from Creative biogene
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Human FAM123A cDNA Clone(NM_152704.2) - CDFG009691 from Creative biogene
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Human FAM123A cDNA Clone(NM_199138.1) - CDFG013049 from Creative biogene
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