| Gene Symbol |
AMER2
|
| Entrez Gene |
219287
|
| Alt Symbol |
FAM123A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
APC membrane recruitment protein 2
|
| Other Description |
family with sequence similarity 123A|protein FAM123A
|
| Swissprots |
Q5RL80 Q5VX56 Q8N7J2 Q8N593 Q96NN5
|
| Accessions |
EAX08363 EAX08364 Q8N7J2 AK055049 BAB70845 AK055278 AK094378 AK098054 AK098343 BAC05288 AK098796 BAC05414 AL832586 AL832627 BC032653 AAH32653 BC041392 AAH41392 BC045677 BM680074 DA210701 XM_005266279 XP_005266336 XM_005266280 XP_005266337 XM_006719770 XP_006719833 NM_152704 NP_689917 NM_199138 NP_954589
|
| Function |
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269|PubMed:22128170}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22128170}; Peripheral membrane protein {ECO:0000269|PubMed:22128170}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
|