TRIB3

Gene Symbol TRIB3
Entrez Gene 57761
Alt Symbol C20orf97, NIPK, SINK, SKIP3, TRB3
Species Human
Gene Type protein-coding
Description tribbles pseudokinase 3
Other Description TRB-3|neuronal cell death inducible putative kinase|neuronal cell death-inducible putative kinase|p65-interacting inhibitor of NF-kappa-B|p65-interacting inhibitor of NF-kappaB|tribbles homolog 3
Swissprots Q6I9Y9 Q53GU4 Q8TAI6 Q9NUD2 Q9H5M8 Q53ZW7 Q96RU7
Accessions CBX54009 EAX10678 Q96RU7 AF250311 AAK58175 AJ697936 CAG27047 AJ697937 AJ697938 AJ697939 AJ697940 AK026945 BAB15597 AK222837 BAD96557 AK297546 BAG59941 AY247738 AAP04407 BC019363 AAH19363 BC027484 AAH27484 BG828172 CR457366 CAG33647 NM_001301188 NP_001288117 NM_001301190 NP_001288119 NM_001301193 NP_001288122 NM_001301196 NP_001288125 NM_001301201 NP_001288130 NM_021158 NP_066981
Function Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.
Subcellular Location Nucleus {ECO:0000269|PubMed:22977230}.
Tissue Specificity Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:12743605, ECO:0000269|PubMed:15299019}.

TRB-3 (C-18) - sc-34212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRB-3 (C-18): sc-34212. Western blot analysis of TRB-3 expression in non-transfected: sc-117752 (A) and human TRB-3 transfected: sc-114588 (B) 293T whole cell lysates.

TRB-3 (E-7) - sc-514455 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRB-3 (E-7): sc-514455. Western blot analysis of TRB-3 expression in Hep G2 whole cell lysate.

TRB-3 (G-10) - sc-271572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRB-3 (G-10): sc-271572. Western blot analysis of TRB-3 expression in non-transfected: sc-117752 (A) and human TRB-3 transfected: sc-114588 (B) 293T whole cell lysates.

TRB-3 (B-2) - sc-390242 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRB-3 (B-2): sc-390242. Western blot analysis of TRB-3 expression in Hep G2 whole cell lysate.

TRB-3 (A-20) - sc-34214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRB-3 (A-20): sc-34214. Western blot analysis of TRB-3 expression in non-transfected: sc-117752 (A) and mouse TRB-3 transfected: sc-127703 (B) 293T whole cell lysates.

TRB-3 (H-140) - sc-67121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRB-3 (H-140): sc-67121. Western blot analysis of TRB-3 expression in non-transfected: sc-117752 (A) and human TRB-3 transfected: sc-114588 (B) 293T whole cell lysates.

TRB-3 (H-19) - sc-34211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRB-3 (H-19): sc-34211. Western blot analysis of TRB-3 expression in c4 (A) and L8 (B) whole cell lysates and rat liver tissue extract (C).

TRB-3 (N-16) - sc-34209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRB-3 (T-15) - sc-34213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRB-3 (T-15): sc-34213. Western blot analysis of truncated TRB-3 expression in non-transfected: sc-117752 (A) and mouse TRB-3 transfected: sc-127703 (B) 293T whole cell lysates.

Anti-TRIB3 antibody - ab137526 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TRIB3 antibody (ab137526) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-TRIB3 antibody - ab73547 from Abcam

Prices $378.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-TRIB3 antibody (ab73547) at 1/500 dilution + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TRIB3 antibody - ab88332 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-TRIB3 antibody (ab88332) at 1 µg/ml + Immunogen (recombinant fragment) at 0.2 µgSecondaryGoat anti-mouse IgG at 1/5000 dilution

Anti-TRIB3 antibody - ab84174 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRIB3 antibody (ab84174) at 1 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TRIB3 antibody - ab57575 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TRIB3 antibody - ab22107 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRIB3 antibody (ab22107) + human liver lysateObserved band size : 40 kDa (why is the actual band size different from the predicted?)

Anti-TRIB3 antibody [EPR3150] - ab75774 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3150
All lanes : Anti-TRIB3 antibody [EPR3150] (ab75774) at 1/1000 dilutionLane 1 : 293T lysates, treated with Ionomycin and TPALane 2 : 293T lysates, untreatedLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/1000 dilution

Anti-TRIB3 antibody [EPR3151Y] - ab75846 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3151Y
All lanes : Anti-TRIB3 antibody [EPR3151Y] (ab75846) at 1/10000 dilutionLane 1 : 293T cell lysates, treated with Ionomycin and TPALane 2 : 293T cell lysates, untreatedLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-TRIB3 antibody - Aminoterminal end - ab50516 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRIB3 antibody - Aminoterminal end (ab50516) at 1/1000 dilutionLane 1 : HEK293 cells transfected with human TRIB3 Lane 2 : HEK293 cells (untransfected) Lane 3 : HEK293 cells transfected with human TRIB3 with TRIB3 immunizing peptide at 20 µg/mlSecondaryGoat Anti-Rabbit IgG, Peroxidase conjugate

Anti-TRB3 / TRIB3 Antibody (Internal) IHC-plus™ - LS-B12111 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of TRB3 in mouse liver tissue with TRB3 antibody at 5 ug/mL.

Anti-TRB3 / TRIB3 Antibody (C-Terminus) - LS-C328946 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRB3 / TRIB3 Antibody (aa56-145, Azide-free) - LS-C328948 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TRB3 / TRIB3 Antibody (N-Terminus) - LS-C330712 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRB3 / TRIB3 Antibody (N-Terminus) IHC-plus™ - LS-A2976 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRIB3 antibody LS-A2976 IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TRB3 / TRIB3 Antibody (C-Terminus) IHC-plus™ - LS-A3372 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRIB3 antibody LS-A3372 IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TRB3 / TRIB3 Antibody (aa15-45) - LS-C100924 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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