TRIB3

Gene Symbol	TRIB3
Entrez Gene	57761
Alt Symbol	C20orf97, NIPK, SINK, SKIP3, TRB3
Species	Human
Gene Type	protein-coding
Description	tribbles pseudokinase 3
Other Description	TRB-3|neuronal cell death inducible putative kinase|neuronal cell death-inducible putative kinase|p65-interacting inhibitor of NF-kappa-B|p65-interacting inhibitor of NF-kappaB|tribbles homolog 3
Swissprots	Q6I9Y9 Q53GU4 Q8TAI6 Q9NUD2 Q9H5M8 Q53ZW7 Q96RU7
Accessions	CBX54009 EAX10678 Q96RU7 AF250311 AAK58175 AJ697936 CAG27047 AJ697937 AJ697938 AJ697939 AJ697940 AK026945 BAB15597 AK222837 BAD96557 AK297546 BAG59941 AY247738 AAP04407 BC019363 AAH19363 BC027484 AAH27484 BG828172 CR457366 CAG33647 NM_001301188 NP_001288117 NM_001301190 NP_001288119 NM_001301193 NP_001288122 NM_001301196 NP_001288125 NM_001301201 NP_001288130 NM_021158 NP_066981
Function	Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22977230}.
Tissue Specificity	Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:12743605, ECO:0000269|PubMed:15299019}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tribbles homolog 3 (TRIB3), Human, ELISA Kit - CSB-EL024446HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 4.68 pg/ml Range 18.75 pg/ml-1200 pg/ml

Tribbles homolog 3, TRIB3, Human, ELISA Kit - E9844h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

TRIB3 (Human) IP-WB Antibody Pair - H00057761-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TRIB3 (Human) Matched Antibody Pair - H00057761-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Tri-iodothyronine, T3, ELISA Kit - MBS700106 from MyBioSource Category ELISA Kit Prices $650.00, $2,295.00, $4,330.00 Sizes 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.249ng/ml Range 0.5 ng/ml-8 ng/ml

Human Tribbles homolog 3(TRIB3) ELISA kit - CSB-EL024446HU from Cusabio Category ELISA Kit Sensitivity 4.68 pg/ml. Range 18.75 pg/ml-1200 pg/ml

Mouse TRB3 / TRIB3 ELISA Kit (Custom ELISA) - LS-F20585 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine TRB3 / TRIB3 ELISA Kit (Custom ELISA) - LS-F20584 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat TRB3 / TRIB3 ELISA Kit (Custom ELISA) - LS-F20586 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

tribbles homolog 3 (Drosophila) , ELISA Kit - MBS932141 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human TRIB3 is typically less than 4.68 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 18.75 pg/ml -1200 pg/ml.

Human Tribbles homolog 3 ELISA Kit - abx251890 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human TRB3 / TRIB3 ELISA Kit (Sandwich ELISA) - LS-F13483 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human Tribbles homolog 3 (TRIB3) ELISA Kit - EKC35878 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 4.68 pg/ml Range 18.75 pg/ml-1200 pg/ml

Human Tribbles homolog 3 ELISA Kit - EKE54563 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.094 ng/mL Range 0.156-10 ng/mL

TRIB3 - EKH5038 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

TRIB3 ELISA Kit (Human) : 96 Wells (OKEH02021) - OKEH02021 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 0.094 ng/mL Range 0.156 - 10 ng/mL

Human TRIB3 ELISA Kit - E039422 from Biobool Category ELISA Kit

Human Tribbles homolog 3 ELISA Kit - EK5052 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Sensitivity less than 0.094ng/mL Range 0.156-10 ng/mL

Tribbles homolog 3, ELISA Kit - MBS2880375 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Tribbles homolog 3, ELISA Kit - MBS9428878 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 0.094ng/mL Range 0.156-10 ng/mL

Tribbles homolog 3, ELISA Kit - MBS764123 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human TRB3 / TRIB3 ELISA Kit (Sandwich ELISA) - LS-F34162 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

Human TRIB3 ELISA Kit - orb405457 from Biorbyt Category ELISA Kit Sensitivity 4.68 pg/ml. Range 18.75 pg/ml-1200 pg/ml

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