| Gene Symbol |
TRIB3
|
| Entrez Gene |
57761
|
| Alt Symbol |
C20orf97, NIPK, SINK, SKIP3, TRB3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tribbles pseudokinase 3
|
| Other Description |
TRB-3|neuronal cell death inducible putative kinase|neuronal cell death-inducible putative kinase|p65-interacting inhibitor of NF-kappa-B|p65-interacting inhibitor of NF-kappaB|tribbles homolog 3
|
| Swissprots |
Q6I9Y9 Q53GU4 Q8TAI6 Q9NUD2 Q9H5M8 Q53ZW7 Q96RU7
|
| Accessions |
CBX54009 EAX10678 Q96RU7 AF250311 AAK58175 AJ697936 CAG27047 AJ697937 AJ697938 AJ697939 AJ697940 AK026945 BAB15597 AK222837 BAD96557 AK297546 BAG59941 AY247738 AAP04407 BC019363 AAH19363 BC027484 AAH27484 BG828172 CR457366 CAG33647 NM_001301188 NP_001288117 NM_001301190 NP_001288119 NM_001301193 NP_001288122 NM_001301196 NP_001288125 NM_001301201 NP_001288130 NM_021158 NP_066981
|
| Function |
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:22977230}.
|
| Tissue Specificity |
Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:12743605, ECO:0000269|PubMed:15299019}.
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