TRIB3

Gene Symbol	TRIB3
Entrez Gene	57761
Alt Symbol	C20orf97, NIPK, SINK, SKIP3, TRB3
Species	Human
Gene Type	protein-coding
Description	tribbles pseudokinase 3
Other Description	TRB-3|neuronal cell death inducible putative kinase|neuronal cell death-inducible putative kinase|p65-interacting inhibitor of NF-kappa-B|p65-interacting inhibitor of NF-kappaB|tribbles homolog 3
Swissprots	Q6I9Y9 Q53GU4 Q8TAI6 Q9NUD2 Q9H5M8 Q53ZW7 Q96RU7
Accessions	CBX54009 EAX10678 Q96RU7 AF250311 AAK58175 AJ697936 CAG27047 AJ697937 AJ697938 AJ697939 AJ697940 AK026945 BAB15597 AK222837 BAD96557 AK297546 BAG59941 AY247738 AAP04407 BC019363 AAH19363 BC027484 AAH27484 BG828172 CR457366 CAG33647 NM_001301188 NP_001288117 NM_001301190 NP_001288119 NM_001301193 NP_001288122 NM_001301196 NP_001288125 NM_001301201 NP_001288130 NM_021158 NP_066981
Function	Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22977230}.
Tissue Specificity	Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:12743605, ECO:0000269|PubMed:15299019}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRIB3 full length protein - ab112420 from Abcam Category Protein Source Wheat germ Species Human

Human TRIB3 full length protein - ab186077 from Abcam Category Protein Species Human

Human TRIB3 full length protein - ab202154 from Abcam Category Protein Source E. coli Species Human

Human TRIB3 protein fragment - ab153464 from Abcam Category Protein Source Wheat germ Species Human

TRIB3 peptide - ab93788 from Abcam Category Peptide

TRIB3 Partial Recombinant Protein - H00057761-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRIB3 Recombinant Protein - H00057761-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRIB3 Peptide - P3192 from Novus Biologicals Category Peptide Species Human

TRIB3 Peptide - P3191 from Novus Biologicals Category Peptide Species Human

TRIB3-Antibody-C-term-Blocking-peptide - BP8157b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIB3-Antibody-N-term-Blocking-peptide - BP8157a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human C20orf97 protein - orb83900 from Biorbyt Category Protein Prices $323.00, $425.00 Sizes 20 μg, 50 μg Source Insect Species Human

TRIB3 Blocking Peptide - 33R-10278 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRIB3 protein (His tag) - 80R-4057 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

TRIB3 Blocking Peptide - abx063932 from Abbexa Category Peptide Species Human, Mouse, Rat

TRIB3 (1-358, His-tag) - AR51742PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

TRIB3 (1-358, His-tag) - AR51742PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

TRIB3 - H00057761-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRIB3 - H00057761-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRIB3 - H00057761-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRIB3 - H00057761-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRB3 Peptide - 8099P from ProSci Category Peptide Species Human

TRIB3 fusion protein - ag4085 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TRIB3, GST tagged - TRIB3-3073H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human TRIB3 - TRIB3-30123TH from Creative Biomart Category Protein Source Wheat germ

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