TRIB3

Gene Symbol	TRIB3
Entrez Gene	57761
Alt Symbol	C20orf97, NIPK, SINK, SKIP3, TRB3
Species	Human
Gene Type	protein-coding
Description	tribbles pseudokinase 3
Other Description	TRB-3|neuronal cell death inducible putative kinase|neuronal cell death-inducible putative kinase|p65-interacting inhibitor of NF-kappa-B|p65-interacting inhibitor of NF-kappaB|tribbles homolog 3
Swissprots	Q6I9Y9 Q53GU4 Q8TAI6 Q9NUD2 Q9H5M8 Q53ZW7 Q96RU7
Accessions	CBX54009 EAX10678 Q96RU7 AF250311 AAK58175 AJ697936 CAG27047 AJ697937 AJ697938 AJ697939 AJ697940 AK026945 BAB15597 AK222837 BAD96557 AK297546 BAG59941 AY247738 AAP04407 BC019363 AAH19363 BC027484 AAH27484 BG828172 CR457366 CAG33647 NM_001301188 NP_001288117 NM_001301190 NP_001288119 NM_001301193 NP_001288122 NM_001301196 NP_001288125 NM_001301201 NP_001288130 NM_021158 NP_066981
Function	Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22977230}.
Tissue Specificity	Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:12743605, ECO:0000269|PubMed:15299019}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRB-3 CRISPR/Cas9 KO Plasmid (h) - sc-401746 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 HDR Plasmid (h) - sc-401746-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 Double Nickase Plasmid (h) - sc-401746-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 Double Nickase Plasmid (h2) - sc-401746-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 CRISPR Activation Plasmid (h) - sc-401746-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 CRISPR Activation Plasmid (h2) - sc-401746-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 Lentiviral Activation Particles (h) - sc-401746-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 Lentiviral Activation Particles (h2) - sc-401746-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRB-3 siRNA (h) - sc-44426 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRB-3 shRNA Plasmid (h) - sc-44426-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRB-3 shRNA (h) Lentiviral Particles - sc-44426-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRIB3 RNAi - H00057761-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TRIB3 RNAi - H00057761-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU013881 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK2330 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2331 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2332 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2473 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2473 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06872 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06872

TRIB3 siRNA (Human) - CRJ1671 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TRIB3 - MBS8211025 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TRIB3 (NM_021158.3) - SHH434340 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TRIB3(NM_021158.3) - SHL093000 from Creative biogene Category siRNA Species Reactivities Human

TRIB3 shRNA Plasmid (Human) - CHJ1671 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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