| Gene Symbol |
TXN
|
| Entrez Gene |
7295
|
| Alt Symbol |
TRDX, TRX, TRX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thioredoxin
|
| Other Description |
ADF|ATL-derived factor|SASP|TXN delta 3|surface-associated sulphydryl protein|thioredoxin delta 3
|
| Swissprots |
Q96KI3 O60744 B1ALW1 Q9UDG5 P10599 Q53X69
|
| Accessions |
AAN33187 CAA38410 EAW59059 EAW59060 P10599 AF065241 AAC17430 AF085844 AF276919 AAF86466 AF313911 AAG34699 AK289508 BAF82197 AW160756 AY004872 AAF87085 BC003377 AAH03377 BC054866 AAH54866 BQ774337 BX647247 CR407665 CAG28593 D28376 BAA05742 J04026 AAA74596 JQ313905 AFH41799 X77584 CAA54687 NM_001244938 NP_001231867 NM_003329 NP_003320
|
| Function |
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
|
| Subcellular Location |
Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
|
![Western Blot: Thioredoxin Overexpression Lysate (Adult Normal) [NBP2-10886] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Thioredoxin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9569_Thioredoxin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10886-img0001.jpg)