TXN

Gene Symbol	TXN
Entrez Gene	7295
Alt Symbol	TRDX, TRX, TRX1
Species	Human
Gene Type	protein-coding
Description	thioredoxin
Other Description	ADF|ATL-derived factor|SASP|TXN delta 3|surface-associated sulphydryl protein|thioredoxin delta 3
Swissprots	Q96KI3 O60744 B1ALW1 Q9UDG5 P10599 Q53X69
Accessions	AAN33187 CAA38410 EAW59059 EAW59060 P10599 AF065241 AAC17430 AF085844 AF276919 AAF86466 AF313911 AAG34699 AK289508 BAF82197 AW160756 AY004872 AAF87085 BC003377 AAH03377 BC054866 AAH54866 BQ774337 BX647247 CR407665 CAG28593 D28376 BAA05742 J04026 AAA74596 JQ313905 AFH41799 X77584 CAA54687 NM_001244938 NP_001231867 NM_003329 NP_003320
Function	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Subcellular Location	Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Thioredoxin / TRX full length protein - ab51064 from Abcam Category Protein Prices $239.00, $588.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Active human Thioredoxin / TRX full length protein - ab95319 from Abcam Category Protein Prices $239.00, $706.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Active human Thioredoxin / TRX full length protein - ab123484 from Abcam Category Protein Prices $192.00 Sizes 5 µg Source E. coli Species Human

Active S. cerevisiae Thioredoxin / TRX full length protein - ab82731 from Abcam Category Protein Prices $239.00 Sizes 500 µg Source E. coli Species Yeast

E. coli Thioredoxin / TRX full length protein - ab115709 from Abcam Category Protein Prices $188.00 Sizes 200 µg Source E. coli Species Escherichia coli

Human Thioredoxin / TRX full length protein - ab172159 from Abcam Category Protein Source E. coli Species Human

Human Thioredoxin / TRX peptide - ab27815 from Abcam Category Peptide

TXN / Thioredoxin / TRX Antibody Blocking Peptide - LS-E2397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Thioredoxin Protein - NBC1-18541 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human Thioredoxin Protein - NBP1-44476 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human Thioredoxin Protein - NBP1-44488 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

Thioredoxin Recombinant Protein - H00007295-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Thioredoxin Partial Recombinant Protein - H00007295-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Thioredoxin Recombinant Protein - P3507 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

Thioredoxin Recombinant Protein - P3454 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

Thioredoxin Recombinant Protein - P4981 from Novus Biologicals Category Protein Prices $549.00 Sizes 50 µg Species Bacteria

Thioredoxin Peptide - P0348 from Novus Biologicals Category Peptide Species Human

Thioredoxin-TRX-Antibody-N-term-Blocking-peptide - BP1337a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Thioredoxin-1, CF - 1970-TX-500 from R&D Systems Category Protein Source E. coli-derived, Val2-Val105

Recombinant Human Thioredoxin 80, CF - 2329-TX-100 from R&D Systems Category Protein Source E. coli-derived, Val2-Lys81

Recombinant human Thioredoxin (OPCA00478) - OPCA00478 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

TXN1 Protein (OPPA01444) - OPPA01444 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

E. coli TXN1 protein - orb81444 from Biorbyt Category Protein Prices $170.00, $289.00, $867.00 Sizes 20 μg, 100 μg, 1 mg Species Escherichia coli

Human TXN protein - orb84580 from Biorbyt Category Protein Prices $298.00, $434.00 Sizes 200 μg, 500 μg Source E. coli Species Human

Human TRX protein - orb245152 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

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